-
公开(公告)号：US20120149879A1
公开(公告)日：2012-06-14
申请号：US13330724
申请日：2011-12-20
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
IPC分类号： C07K16/46
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and methods of treatment using the antibodies.
摘要翻译： 本发明涉及针对EGFR和针对IGF-1R的双特异性抗体，其制备方法，含有所述抗体的药物组合物和使用该抗体的治疗方法。
-
公开(公告)号：US09050375B2
公开(公告)日：2015-06-09
申请号：US13382505
申请日：2010-06-30
申请人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： C07K16/46 , A61K49/00 , A61K49/16 , A61K47/48 , A61K31/704 , A61K39/395 , B82Y5/00 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C12N15/11 , C12N15/113 , A61K39/00
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对靶蛋白和半抗原的双特异性抗体和抗体片段，其中半抗原为PEG或生物素，最优选为地高辛，其制备方法，用作治疗或诊断试剂的递送平台，含有所述 抗体及其用途。
-
公开(公告)号：US20130022601A1
公开(公告)日：2013-01-24
申请号：US13568224
申请日：2012-08-07
申请人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： C07K16/46 , A61P35/00 , C12N15/62 , A61K39/395
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及三价，双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
-
公开(公告)号：US20100081796A1
公开(公告)日：2010-04-01
申请号：US12565786
申请日：2009-09-24
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
IPC分类号： C07K16/18
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and methods of treatment using the antibodies.
摘要翻译： 本发明涉及针对EGFR和针对IGF-1R的双特异性抗体，其制备方法，含有所述抗体的药物组合物和使用该抗体的治疗方法。
-
5.发明授权Peptides containing an arginine mimetic for the treatment of bone metabolic disorders, their production, and drugs containing these compounds 失效含有精氨酸模拟物的肽用于治疗骨代谢紊乱，其生产和含有这些化合物的药物公开(公告)号：US06429288B1
公开(公告)日：2002-08-06
申请号：US09486679
申请日：2000-03-31
IPC分类号： C07K508
CPC分类号： C07D403/12 , A61K38/00 , C07D207/20 , C07K5/0205 , C07K5/0207 , C07K5/1024 , C07K14/635
摘要： Arginine mimetic peptides according to Formula I of this application have a stimulating effect on bone formation and are useful for the treatment of bone metabolic disorders.
摘要翻译： 根据本申请式I的精氨酸模拟肽对骨形成具有刺激作用，并且可用于治疗骨代谢紊乱。
-
公开(公告)号：US09890204B2
公开(公告)日：2018-02-13
申请号：US13568224
申请日：2012-08-07
申请人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Eike Hoffmann , Christian Klein , Ekkehard Moessner , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
-
7.发明授权Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent 有权缀合于治疗或诊断剂的双特异性抗体和地高辛的复合物公开(公告)号：US08907069B2
公开(公告)日：2014-12-09
申请号：US13382502
申请日：2010-07-05
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： C07K16/46 , A61K51/10 , A61K49/00 , A61K47/48 , C07K16/28 , B82Y5/00 , C12N15/113 , A61K39/395 , C07K16/16 , C07K16/44 , C07K16/32 , C12N15/11 , A61K31/704 , A61K39/00
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途， 含有所述抗体的药物组合物及其用途。
-
公开(公告)号：US07956190B2
公开(公告)日：2011-06-07
申请号：US12600662
申请日：2008-06-23
申请人： Guy Georges , Eike Hoffmann , Klaus Kaluza , Matthias Koerner , Ulrike Reiff , Stefan Weigand
发明人： Guy Georges , Eike Hoffmann , Klaus Kaluza , Matthias Koerner , Ulrike Reiff , Stefan Weigand
IPC分类号： C07D401/00
CPC分类号： C07D401/14 , C07D401/04
摘要： Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明的目的是式（I）化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备方法，以及上述用途， 提及的化合物在控制或预防诸如癌症的疾病中。
-
公开(公告)号：US20060116407A1
公开(公告)日：2006-06-01
申请号：US11274497
申请日：2005-11-15
IPC分类号： A61K31/427 , A61K31/422 , C07D417/02 , C07D413/02
CPC分类号： C07D413/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention relates to the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.
摘要翻译： 本发明涉及式I化合物的药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物组合物及其制备方法以及上述化合物 控制或预防癌症等疾病。
-
10.发明授权Exendin analogues, processes for their preparation and medicaments containing them 失效毒蜥外泌肽类似物，其制备方法和含有它们的药物公开(公告)号：US06767887B1
公开(公告)日：2004-07-27
申请号：US09147345
申请日：1999-06-04
IPC分类号： A61K3816
CPC分类号： C07K14/57563 , A61K38/00 , Y10S514/866
摘要： The invention concerns exendin analogues which can be used in the treatment of diabetes mellitus. The invention also concerns processes for preparing these substances and medicaments containing them. The exendin analogues are derived from SEQ ID:1(I) or SEQ ID:2(II).
摘要翻译： 本发明涉及可用于治疗糖尿病的毒蜥外泌肽类似物。 本发明还涉及制备这些物质和含有它们的药物的方法。 毒蜥外泌肽类似物衍生自SEQ ID：1（I）或SEQ ID：2（II）。
-
-
-
-
-
-
-
-
-
搜索结果
13 条记录 (耗时 0.027 秒)
