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公开(公告)号：US09109027B2
公开(公告)日：2015-08-18
申请号：US13548244
申请日：2012-07-13
Applicant: Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
Inventor： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
IPC: A61K39/395 , C07K16/22 , A61K39/00 , C12N15/85
CPC classification number: C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
Abstract: The present invention relates to a method of treating a disease or disorder in a patient comprising administering, to a patient in need of such treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2). The present invention also relates to a method for preventing metastasis in a patient suffering from primary cancer comprising administering, to a patient in need of such preventative treatment, an antibody which binds specifically to human angiopoietin-2 (ANG-2).
Abstract translation: 本发明涉及一种治疗患者疾病或病症的方法，包括向需要这种治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。 本发明还涉及一种用于预防患有原发性癌症的患者转移的方法，包括向需要这种预防性治疗的患者施用特异性结合人血管生成素-2（ANG-2）的抗体。
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公开(公告)号：US08703130B2
公开(公告)日：2014-04-22
申请号：US13570333
申请日：2012-08-09
Applicant: Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
Inventor： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC: A61K39/395
CPC classification number: C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
Abstract: The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Abstract translation: 本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20120226119A1
公开(公告)日：2012-09-06
申请号：US13383197
申请日：2010-07-09
Applicant: Michael Dobosz , Christian Kein , Johannes Sam , Werner Scheuer
Inventor： Michael Dobosz , Christian Kein , Johannes Sam , Werner Scheuer
CPC classification number: A61K49/0058
Abstract: The present invention relates to non-invasive methods of and uses for in vivo imaging tumor vasculature in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In a further aspect the present invention relates to non-invasive methods of and uses for in vivo monitoring the therapeutic efficacy of an anti-angiogenic agent in a subject comprising detecting a fluorescence labelled anti-CD31 antibody. In addition, a kit for use in the methods of the present invention is provided which comprises a fluorescence labelled anti-CD31 antibody and means for near-infrared fluorescence imaging to detect the antibody in a subject.
Abstract translation: 本发明涉及用于体内成像肿瘤脉管系统的非侵入性方法和用途，其包括检测荧光标记的抗CD31抗体。 在另一方面，本发明涉及用于体内监测受试者中抗血管生成剂的治疗功效的非侵入性方法和用途，所述方法包括检测荧光标记的抗CD31抗体。 此外，提供了用于本发明方法的试剂盒，其包含荧光标记的抗CD31抗体和用于近红外荧光成像的装置，以检测受试者中的抗体。
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公开(公告)号：US20120141500A1
公开(公告)日：2012-06-07
申请号：US13358831
申请日：2012-01-26
Applicant: ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
Inventor： ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
CPC classification number: C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
Abstract: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Abstract translation: 本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。
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公开(公告)号：US20120142091A1
公开(公告)日：2012-06-07
申请号：US13358813
申请日：2012-01-26
Applicant: ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
Inventor： ULRICH BRINKMANN , REMKO ALBERT GRIEP , KLAUS KALUZA , ANITA KAVLIE , CHRISTIAN KLEIN , JOERG THOMAS REGULA , WERNER SCHEUER
CPC classification number: C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
Abstract: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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Patent Agency Ranking
6.发明申请BISPECIFIC, BIVALENT ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 有权BISPECIFIC，BIVALENT ANTI-VEGF / ANTI-ANG-2 ANTIBODIES公开(公告)号：US20110236388A1
公开(公告)日：2011-09-29
申请号：US13071127
申请日：2011-03-24
Applicant: Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Kay-Gunnar Stubenrauch , Markus Thomas
Inventor： Monika Baehner , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Kay-Gunnar Stubenrauch , Markus Thomas
IPC: A61K39/395 , C07K16/22 , C07H21/00 , A61P9/00 , A61P35/00 , C12N15/63 , C12P21/02 , C12N5/10 , C12N1/00
CPC classification number: C07K16/22 , A61K2039/505 , C07K16/3015 , C07K16/3046 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Abstract translation: 本发明涉及针对人血管内皮生长因子（VEGF / VEGF-A）和针对人血管生成素-2（ANG-2）的双特异性二价抗体，其生产方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20110223159A1
公开(公告)日：2011-09-15
申请号：US13111784
申请日：2011-05-19
Applicant: Thomas Friess , Max Hasmann , Werner Scheuer
Inventor： Thomas Friess , Max Hasmann , Werner Scheuer
IPC: A61K39/395 , A61P35/00 , A61P35/04
CPC classification number: C07K16/22 , A61K39/3955 , A61K2039/505 , A61K2039/545 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides a method of treating a patient suffering from relapsed HER2 positive cancer with an anti-VEGF antibody during or after treatment with an anti-HER2 antibody. The invention also provides a kit comprising an anti-VEGF antibody.
Abstract translation: 本发明提供了在用抗HER2抗体治疗期间或之后用抗VEGF抗体治疗患有复发性HER2阳性癌症的患者的方法。 本发明还提供了包含抗VEGF抗体的试剂盒。
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8.发明申请TUMOR THERAPY WITH AN ANTIBODY FOR VASCULAR ENDOTHELIAL GROWTH FACTOR AND AN ANTIBODY FOR HUMAN EPITHELIAL GROWTH FACTOR RECEPTOR TYPE 2 审中-公开肿瘤治疗与血管内皮生长因子和人类上皮生长因子受体2型抗体的抗体公开(公告)号：US20110064736A1
公开(公告)日：2011-03-17
申请号：US12947264
申请日：2010-11-16
Applicant: Thomas Friess , Max Hasmann , Werner Scheuer
Inventor： Thomas Friess , Max Hasmann , Werner Scheuer
IPC: A61K39/395 , A61P35/00
CPC classification number: A61K39/39558 , A61K39/3955 , A61K2039/507 , C07K16/22 , C07K16/3015 , C07K16/32 , C07K2317/24
Abstract: The present invention provides a method of treating a breast cancer disease in a patient who has failed prior treatment with an anti-VEGF antibody, comprising administering to the patient a therapeutically effective amount of an anti-HER2 antibody while continuing said anti-VEGF antibody therapy. The invention also provides corresponding pharmaceutical kits and pharmaceutical compositions.
Abstract translation: 本发明提供了一种治疗患有先前用抗VEGF抗体治疗失败的患者的乳腺癌疾病的方法，其包括向患者施用治疗有效量的抗HER2抗体，同时继续进行所述抗VEGF抗体治疗 。 本发明还提供相应的药物试剂盒和药物组合物。
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公开(公告)号：US20100159587A1
公开(公告)日：2010-06-24
申请号：US12635825
申请日：2009-12-11
Applicant: Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
Inventor： Ulrich Brinkmann , Remko Albert Griep , Klaus Kaluza , Anita Kavlie , Christian Klein , Joerg Thomas Regula , Werner Scheuer
CPC classification number: C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
Abstract: The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
Abstract translation: 本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。
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10.发明授权公开(公告)号：US09339560B2
公开(公告)日：2016-05-17
申请号：US13061770
申请日：2009-09-21
Applicant: Birgit Bossenmaier , Valeria Lifke , Werner Scheuer
Inventor： Birgit Bossenmaier , Valeria Lifke , Werner Scheuer
IPC: A61K39/395 , A61K49/16 , A61K49/00 , C07K16/32 , A61K39/00
CPC classification number: A61K49/0008 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/545 , C07K16/32
Abstract: The present invention relates to a method for determining the anti-tumor efficacy of monoclonal antibodies in pre-clinical rodent testings and the use of said method for the reduction of side testings.
Abstract translation: 本发明涉及用于确定单克隆抗体在临床前啮齿动物试验中的抗肿瘤功效的方法，以及所述用于减少侧面试验的方法。
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