Embodiments of the present invention provide an interference elimination method, an interference elimination device and a communication system, which are used to implement the effective elimination of signal interference of a receiving end. The method includes: according to a received signal, reconstructing a main cell signal, obtaining the reconstructed main cell signal, and subtracting the reconstructed main cell signal from the received signal, so as to obtain a first residual signal; according to the first residual signal, reconstructing an interference cell signal, and obtaining the reconstructed interference cell signal; and according to the received signal and the reconstructed interference cell signal, obtaining an interference-eliminated main cell signal. According to the interference elimination method, the interference elimination device and the communication system in the embodiments of the present invention, the interference elimination may be performed on the received signal effectively.