发明授权
US08932836B2 Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
有权
用于合成（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的生物催化剂和方法
- 专利标题： Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
- 专利标题（中）： 用于合成（1R，2R）-2-（3,4-二甲氧基苯乙氧基）环己胺的生物催化剂和方法
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申请号： US13817295申请日： 2011-08-08
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公开(公告)号： US08932836B2公开(公告)日： 2015-01-13
- 发明人: John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
- 申请人： John Limanto , Gregory Beutner , Brendan Grau , Jacob Janey , Artis Klapars , Eric R. Ashley , Hallena R. Strotman , Matthew D. Truppo , Gregory Hughes , Fabien Cabirol , Anupam Gohel , Steven J. Collier , Jack Liang , Marissa Mock , Emily Mundorff , Scott Novick , Derek Smith
- 申请人地址： US CA Redwood City
- 专利权人： Codexis, Inc.
- 当前专利权人： Codexis, Inc.
- 当前专利权人地址： US CA Redwood City
- 代理机构： Codexis, Inc.
- 国际申请： PCT/US2011/046932 WO 20110808
- 国际公布： WO2012/024104 WO 20120223
- 主分类号： C12N9/10
- IPC分类号： C12N9/10 ; C12P13/00
摘要：
The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine in at least a 2:1 diastereomeric ratio relative to the cis diastereomer (1R,2S)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine. The disclosure also provides polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides in processes for preparing (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine and its analogs, which can product compounds can be further used to prepare the aminocyclohexylether compound, (3R)-1-[(1R,2R)-2-[2-(3,4-dimethoxyphenyl)ethoxy]cyclohexyl]pyrrolidin-3-ol, which is an ion channel blocker.
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