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    Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates
    5.
    发明授权
    Synthesis of spiro ortho esters, spiro ortho carbonates, and intermediates 有权
    螺原酸酯，原碳酸酯和中间体的合成

    公开(公告)号：US06613918B1

    公开(公告)日：2003-09-02

    申请号：US09982827

    申请日：2001-10-22

    申请人： Robert Seemayer ,  Jack Liang

    发明人： Robert Seemayer ,  Jack Liang

    IPC分类号： C07D49300

    CPC分类号： C07D493/04 ,  C07D493/10

    摘要： Ortho esters and ortho carbonates can be produced by alkylating esters and carbonates with, for example, the hexafluorophosphate salt of a trialkyl oxonium ion. The spiro species are useful intermediates in the synthesis of complex organic molecules. Synthetic pathways for the production of medically active compounds incorporates spiro ortho esters. Anti-first-pass effect materials are produced in high yield utilizing a synthetic strategy incorporating cyclic ortho ester intermediates.

    摘要翻译： 可以通过用例如三烷基氧鎓离子的六氟磷酸盐将酯和碳酸酯烷基化来制备原酸酯和原碳酸酯。 螺状物质是合成有机分子的有用中间体。 用于制备医药活性化合物的合成途径包括螺原酸酯。 使用结合环状原酸酯中间体的合成策略，以高产率生产抗首过效应材料。

    Highly stable β-class carbonic anhydrases useful in carbon capture systems
    8.
    发明授权
    Highly stable β-class carbonic anhydrases useful in carbon capture systems 有权
    高度稳定的碳酸酐酶可用于碳捕获系统

    公开(公告)号：US08354261B2

    公开(公告)日：2013-01-15

    申请号：US13174479

    申请日：2011-06-30

    申请人： Oscar Alvizo ,  Mike Benoit ,  Irene Fusman ,  Jack Liang ,  Luan Nguyen ,  Scott Novick

    发明人： Oscar Alvizo ,  Mike Benoit ,  Irene Fusman ,  Jack Liang ,  Luan Nguyen ,  Scott Novick

    IPC分类号： C12N9/00 ,  C12N1/20 ,  C12P1/00

    CPC分类号： C12Y402/01001 ,  C12N9/88

    摘要： The present disclosure relates to β-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas stream into a solution as well as for the release of the absorbed carbon dioxide for further treatment and/or sequestering. Also provided are polynucleotides encoding the carbonic anhydrase polypeptides and host cells capable of expressing them.

    摘要翻译： 本公开涉及具有改进性质的碳酸酐酶多肽类，包括在胺化合物，氨或碳酸根离子存在下增加的热稳定性和/或稳定性。 本公开还提供了多肽的制剂和用途，用于加速二氧化碳从气流吸收到溶液中以及释放吸收的二氧化碳用于进一步处理和/或螯合。 还提供了编码碳酸酐酶多肽和能够表达它们的宿主细胞的多核苷酸。