发明授权
US08940789B2 Neurite elongation agent, memory-improving agent and anti-Alzheimer agent comprising 4′-demethylnobiletin or 4′-demethyltangeretin as active ingredient, and process for production of the compound
有权
神经突伸剂，记忆改善剂和包含4'-去甲基异烟肼或4'-去甲基倍他宁作为活性成分的抗阿尔茨海默病药，以及该化合物的制备方法
- 专利标题： Neurite elongation agent, memory-improving agent and anti-Alzheimer agent comprising 4′-demethylnobiletin or 4′-demethyltangeretin as active ingredient, and process for production of the compound
- 专利标题（中）： 神经突伸剂，记忆改善剂和包含4'-去甲基异烟肼或4'-去甲基倍他宁作为活性成分的抗阿尔茨海默病药，以及该化合物的制备方法
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申请号： US13321988申请日： 2010-03-10
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公开(公告)号： US08940789B2公开(公告)日： 2015-01-27
- 发明人: Shuichi Kusano , Hiroshi Tamura
- 申请人： Shuichi Kusano , Hiroshi Tamura
- 申请人地址： JP Marugame-shi, Kagawa
- 专利权人： Fuji Sangyo Co., Ltd.
- 当前专利权人： Fuji Sangyo Co., Ltd.
- 当前专利权人地址： JP Marugame-shi, Kagawa
- 代理机构： Holtz, Holtz, Goodman & Chick PC
- 优先权： JP2009-133598 20090603
- 国际申请： PCT/JP2010/053958 WO 20100310
- 国际公布： WO2010/140409 WO 20101209
- 主分类号： A61K31/352
- IPC分类号： A61K31/352 ; A61P25/00 ; A61P25/28 ; C12P17/06 ; C07D311/30 ; A61K36/062 ; A61K36/752
摘要：
A method for producing 4′-demethylnobiletin or 4′-demethyltangeretin including fermenting a skin derived from at least one citrus fruit selected from citrus fruits belonging to section Acrumen in subgenus Metacitrus in genus Citrus or citrus fruits belonging to section Aurantium in subgenus Archicitrus in genus Citrus, or a water extract product thereof using one or more Aspergillus molds selected from Aspergillus kawachii, Aspergillus awamori, Aspergillus oryzae, Aspergillus sojae, Aspergillus saitoi, and Aspergillus usamii to obtain a fermented product.
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