One embodiment sets forth a timing calibration technique for on-chip source-synchronous, complementary metal-oxide-semiconductor (CMOS) repeater-based interconnect. Two transition patterns may be applied to calibrate the delay of an on-chip data or clock wire. Calibration logic is configured to apply the transition patterns and then trim the delays of the clock and data wires based on captured calibration patterns. The trimming adjusts the delay of the clock and data wires using a configurable delay circuit. Timing errors may be caused by crosstalk, power-supply-induced jitter (PSIJ), or wire delay variation due to transistor and wire metallization mismatch. Chip yields may be improved by reducing the occurrence of timing errors due to mismatched delays between different wires of an on-chip interconnect.