Invention Grant
- Patent Title: Chroman derivatives as TRPM8 inhibitors
- Patent Title (中): 色甘酸衍生物作为TRPM8抑制剂
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Application No.: US13958478Application Date: 2013-08-02
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Publication No.: US08952009B2Publication Date: 2015-02-10
- Inventor: Kaustav Biswas , Jian J. Chen , Vijay Keshav Gore , Scott Harried , Daniel B. Horne , Matthew R. Kaller , Vu Van Ma , Kelvin Sham , Wenge Zhong
- Applicant: Amgen Inc.
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Bernard P. Friedrichsen
- Main IPC: C07D491/052
- IPC: C07D491/052 ; C07D401/12 ; C07D311/68 ; C07D215/40 ; C07D471/04 ; C07D491/04
Abstract:
Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.
Public/Granted literature
- US20140045855A1 CHROMAN DERIVATIVES AS TRPM8 INHIBITORS Public/Granted day:2014-02-13
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