发明授权
- 专利标题： Designer osteogenic proteins
- 专利标题（中）： 设计师成骨蛋白
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申请号： US13211755申请日： 2011-08-17
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公开(公告)号： US08952131B2公开(公告)日： 2015-02-10
- 发明人: Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie P. Calabro , Christopher Todd Brown
- 申请人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie P. Calabro , Christopher Todd Brown
- 申请人地址： US NJ Madison
- 专利权人： Wyeth LLC
- 当前专利权人： Wyeth LLC
- 当前专利权人地址： US NJ Madison
- 代理机构： Kacvinsky Daisak Bluni PLLC
- 主分类号： C07K14/51
- IPC分类号： C07K14/51 ; C07H21/04 ; A61K38/18 ; A61P19/08 ; A61K38/00
摘要：
The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
公开/授权文献
- US20120046227A1 DESIGNER OSTEOGENIC PROTEINS 公开/授权日：2012-02-23