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公开(公告)号：US08952131B2
公开(公告)日：2015-02-10
申请号：US13211755
申请日：2011-08-17
申请人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie P. Calabro , Christopher Todd Brown
发明人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie P. Calabro , Christopher Todd Brown
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译： 本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其使用方法。 更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。 设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。
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公开(公告)号：US20120046227A1
公开(公告)日：2012-02-23
申请号：US13211755
申请日：2011-08-17
申请人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie Calabro , Christopher Todd Brown
发明人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie Calabro , Christopher Todd Brown
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译： 本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其使用方法。 更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。 设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。
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公开(公告)号：US20160207973A1
公开(公告)日：2016-07-21
申请号：US14589468
申请日：2015-01-05
申请人： Stephen BERASI , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
发明人： Stephen BERASI , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
IPC分类号： C07K14/51
CPC分类号： C07K14/51
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译： 本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其用途的方法。 更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。 设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。
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公开(公告)号：US09688735B2
公开(公告)日：2017-06-27
申请号：US14589468
申请日：2015-01-05
申请人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
发明人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
CPC分类号： C07K14/51
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
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公开(公告)号：US20170209623A1
公开(公告)日：2017-07-27
申请号：US15339834
申请日：2016-10-31
申请人： Eric Vanderploeg , Howard Seeherman , Christopher G. Wilson , John Wozney , Christopher Todd Brown
发明人： Eric Vanderploeg , Howard Seeherman , Christopher G. Wilson , John Wozney , Christopher Todd Brown
CPC分类号： A61L27/56 , A61L24/0015 , A61L24/0036 , A61L24/0073 , A61L27/10 , A61L27/24 , A61L27/46 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2430/02
摘要： Systems and methods for preparing osteoinductive synthetic bone grafts are provided in which a porous ceramic granule, which may be incorporated within a biocompatible matrix material, is loaded with an osteoinductive agent. Loading of granules is facilitated in some cases by the use of low-pH buffers and pre-treatments.
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公开(公告)号：US20160052984A1
公开(公告)日：2016-02-25
申请号：US14679705
申请日：2015-04-06
IPC分类号： C07K14/51
CPC分类号： C07K14/51 , A61K38/00 , A61K38/1875 , C12N15/09
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译： 本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其使用方法。 更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。 设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。
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公开(公告)号：US20100286071A1
公开(公告)日：2010-11-11
申请号：US12817718
申请日：2010-06-17
申请人： Zhijian Lu , Wei Liu , Jimin Zhang , Paul John Yaworsky , Stephane H. Olland , Christopher Todd Brown , Emily Sheng-ming Shen
发明人： Zhijian Lu , Wei Liu , Jimin Zhang , Paul John Yaworsky , Stephane H. Olland , Christopher Todd Brown , Emily Sheng-ming Shen
CPC分类号： C07K1/22 , A61K38/00 , C07K14/475 , C07K14/495 , C07K14/51
摘要： Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.
摘要翻译： TGF-和bgr的成员 使用基于成员蛋白的超家族和肽片段来纯化含有成员蛋白质的溶液或作为治疗剂。
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公开(公告)号：US07754689B2
公开(公告)日：2010-07-13
申请号：US11809383
申请日：2007-06-01
申请人： Zhijian Lu , Wei Liu , Jimin Zhang , Paul John Yaworsky , Stephane H. Olland , Christopher Todd Brown , Emily Sheng-ming Shen
发明人： Zhijian Lu , Wei Liu , Jimin Zhang , Paul John Yaworsky , Stephane H. Olland , Christopher Todd Brown , Emily Sheng-ming Shen
CPC分类号： C07K1/22 , A61K38/00 , C07K14/475 , C07K14/495 , C07K14/51
摘要： Members of the TGF-β superfamily and peptide fragments based on member proteins are employed to purify solutions containing member proteins or as therapeutics.
摘要翻译： TGF-和bgr的成员 使用基于成员蛋白的超家族和肽片段来纯化含有成员蛋白质的溶液或作为治疗剂。
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