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公开(公告)号：US09688735B2
公开(公告)日：2017-06-27
申请号：US14589468
申请日：2015-01-05
申请人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
发明人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
CPC分类号： C07K14/51
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
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公开(公告)号：US09315301B1
公开(公告)日：2016-04-19
申请号：US14299499
申请日：2014-06-09
CPC分类号： A45C11/20 , A45F5/021 , A45F2200/0566 , A45F2200/0583
摘要： A snack bottle with distensible dispensing cap that includes a deformable container portion attachable to a rubberlike dispensing cap, said dispensing cap having a slit opening rendered linearly therein, wherein deformation of the container portion by application of manual pressure thereto distends the slit opening in the dispensing cap, and snacks additional to the container portion are transmissible through the dispensing cap when the slit opening is distended, whereby snacks storable within the container portion are dispensable singlehandedly from said container portion.
摘要翻译： 一种具有可扩张分配帽的快餐瓶，其包括可附接到橡胶状分配帽的可变形容器部分，所述分配帽具有在其中线性呈现的狭缝开口，其中通过施加手动压力使容器部分发生变形，使得分配中的狭缝开口 当狭缝开口膨胀时，容器部分附加的帽子和小吃可以通过分配帽传播，从而可容纳在容器部分内的小食从所述容器部分单独地分配。
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公开(公告)号：US08952131B2
公开(公告)日：2015-02-10
申请号：US13211755
申请日：2011-08-17
申请人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie P. Calabro , Christopher Todd Brown
发明人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie P. Calabro , Christopher Todd Brown
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译： 本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其使用方法。 更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。 设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。
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公开(公告)号：US20120046227A1
公开(公告)日：2012-02-23
申请号：US13211755
申请日：2011-08-17
申请人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie Calabro , Christopher Todd Brown
发明人： Stephen Berasi , Robert Vincent Martinez , Michael John Cain , John Wozney , Howard Seeherman , Z. Sean Juo , Valerie Calabro , Christopher Todd Brown
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译： 本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其使用方法。 更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。 设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。
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公开(公告)号：US20160207973A1
公开(公告)日：2016-07-21
申请号：US14589468
申请日：2015-01-05
申请人： Stephen BERASI , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
发明人： Stephen BERASI , Robert Vincent Martinez , Michael John Cain , John Martin Wozney , Howard Joel Seeherman , Zong Sean Juo , Valerie Perrine Calabro , Christopher Todd Brown
IPC分类号： C07K14/51
CPC分类号： C07K14/51
摘要： The invention relates to novel designer osteogenic proteins having altered affinity for a cognate receptor, nucleic acids encoding the same, and methods of use therefor. More preferably, the novel designer osteogenic proteins are designer BMPs and have altered affinity for a cognate BMP receptor. The designer BMPs demonstrate altered biological characteristics and provide potential useful novel therapeutics.
摘要翻译： 本发明涉及对同型受体具有改变的亲和力的新型设计者成骨蛋白质，及其编码的核酸及其用途的方法。 更优选地，新设计的成骨蛋白是设计者BMP并且对同源BMP受体具有改变的亲和力。 设计者BMPs展示了改变的生物学特征，并提供潜在的有用的新型治疗。
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