发明授权
US08962598B2 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as AHR activators
有权
1,2-二氢-4-羟基-2-氧代喹啉-3-甲酰苯胺作为AHR活化剂
- 专利标题： 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as AHR activators
- 专利标题（中）： 1,2-二氢-4-羟基-2-氧代喹啉-3-甲酰苯胺作为AHR活化剂
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申请号： US13824256申请日： 2011-10-11
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公开(公告)号： US08962598B2公开(公告)日： 2015-02-24
- 发明人: Lars Pettersson
- 申请人： Lars Pettersson
- 申请人地址： SE Lund
- 专利权人： Immunahr AB
- 当前专利权人： Immunahr AB
- 当前专利权人地址： SE Lund
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 优先权： SE1001012 20101014
- 国际申请： PCT/SE2011/000179 WO 20111011
- 国际公布： WO2012/050500 WO 20120419
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; C07D513/02 ; C07D215/00 ; C07D215/56 ; C07D495/04 ; C07F9/60
摘要：
The present invention relates to compounds which are 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides, their thieno-pyridone analogs, and prodrugs thereof. This invention specifically relates to such derivatives containing an N-hydrogen in the carboxanilide moiety and which exhibit modulating activity towards the aromatic hydrocarbon receptor (AhR), and, specifically, also to prodrugs thereof. The present invention also relates to use of said compounds as a medicament, and for the treatment of cancer, autoimmune disorders and other disorders with an immunological component, and a pharmaceutical composition comprising one or more of said compounds and a method of treatment.