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    1,2-DIHYDRO-4-HYDROXY-2-OXO-QUINOLINE-3-CARBOXANILIDES AS AHR ACTIVATORS
    1.
    发明申请
    1,2-DIHYDRO-4-HYDROXY-2-OXO-QUINOLINE-3-CARBOXANILIDES AS AHR ACTIVATORS 有权
    1,2-二羟基-4-羟基-2-氧喹啉-3-羧酸酯作为AHR激活剂

    公开(公告)号：US20130203703A1

    公开(公告)日：2013-08-08

    申请号：US13824256

    申请日：2011-10-11

    申请人： Lars Pettersson

    发明人： Lars Pettersson

    IPC分类号： C07D215/56 ,  C07F9/60 ,  C07D495/04

    CPC分类号： C07D215/56 ,  C07D495/04 ,  C07F9/60

    摘要： The present invention relates to compounds which are 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides, their thieno-pyridone analogs, and prodrugs thereof. This invention specifically relates to such derivatives containing an N-hydrogen in the carboxanilide moiety and which exhibit modulating activity towards the aromatic hydrocarbon receptor (AhR), and, specifically, also to prodrugs thereof. The present invention also relates to use of said compounds as a medicament, and for the treatment of cancer, autoimmune disorders and other disorders with an immunological component, and a pharmaceutical composition comprising one or more of said compounds and a method of treatment.

    摘要翻译： 本发明涉及1,2-二氢-4-羟基-2-氧代喹啉-3-甲酰苯胺化合物，其噻吩并吡啶酮类似物及其前药。 本发明具体涉及在羧酰苯胺部分中含有N-氢的衍生物，其表现出对芳香族烃受体（AhR）的调节活性，特别涉及其前药。 本发明还涉及所述化合物作为药物以及用免疫组分治疗癌症，自身免疫疾病和其它病症以及包含一种或多种所述化合物和治疗方法的药物组合物的用途。

    Steroids for cancer treatment
    2.
    发明申请
    Steroids for cancer treatment 审中-公开
    类固醇用于癌症治疗

    公开(公告)号：US20070142345A1

    公开(公告)日：2007-06-21

    申请号：US10587561

    申请日：2005-02-11

    申请人： Lars Pettersson

    发明人： Lars Pettersson

    IPC分类号： A61K31/56 ,  C07J53/00

    CPC分类号： C07J53/00 ,  C07J3/00

    摘要： The present invention relates to novel compounds which are 7α-substituted 17-alkylene-16α-hydroxy steroidal estrogens. This invention specifically relates to estrogen derivatives which contain 7α-substituents and which exhibit anti-estrogenic properties. The present invention also relates to use of said compounds as a medicament, and for the treatment of estrogen dependent disorders, a pharmaceutical composition comprising one or more of said compounds and a method of treatment.

    摘要翻译： 本发明涉及7α-取代的17-亚烷基-16α-羟基甾体雌激素的新化合物。 本发明具体涉及含有7α-取代基并表现出抗雌激素特性的雌激素衍生物。 本发明还涉及所述化合物作为药物和治疗雌激素依赖性病症的用途，包含一种或多种所述化合物的药物组合物和治疗方法。

    1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as AHR activators
    5.
    发明授权
    1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as AHR activators 有权
    1,2-二氢-4-羟基-2-氧代喹啉-3-甲酰苯胺作为AHR活化剂

    公开(公告)号：US08962598B2

    公开(公告)日：2015-02-24

    申请号：US13824256

    申请日：2011-10-11

    申请人： Lars Pettersson

    发明人： Lars Pettersson

    IPC分类号： A61K31/675 ,  C07D513/02 ,  C07D215/00 ,  C07D215/56 ,  C07D495/04 ,  C07F9/60

    CPC分类号： C07D215/56 ,  C07D495/04 ,  C07F9/60

    摘要： The present invention relates to compounds which are 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides, their thieno-pyridone analogs, and prodrugs thereof. This invention specifically relates to such derivatives containing an N-hydrogen in the carboxanilide moiety and which exhibit modulating activity towards the aromatic hydrocarbon receptor (AhR), and, specifically, also to prodrugs thereof. The present invention also relates to use of said compounds as a medicament, and for the treatment of cancer, autoimmune disorders and other disorders with an immunological component, and a pharmaceutical composition comprising one or more of said compounds and a method of treatment.

    摘要翻译： 本发明涉及1,2-二氢-4-羟基-2-氧代喹啉-3-甲酰苯胺化合物，其噻吩并吡啶酮类似物及其前药。 本发明具体涉及在羧酰苯胺部分中含有N-氢的衍生物，其表现出对芳香族烃受体（AhR）的调节活性，特别涉及其前药。 本发明还涉及所述化合物作为药物以及用免疫组分治疗癌症，自身免疫疾病和其它病症以及包含一种或多种所述化合物和治疗方法的药物组合物的用途。

    Method and system for systematic evaluation of evaluation parameters of technical operational equipment
    7.
    发明授权
    Method and system for systematic evaluation of evaluation parameters of technical operational equipment 有权
    技术作业设备评价参数系统评价方法与系统

    公开(公告)号：US07239977B2

    公开(公告)日：2007-07-03

    申请号：US10547478

    申请日：2004-04-06

    申请人： Nicolaie Laurentiu Fantana ,  Lars Pettersson ,  Mark D. Perkins ,  Ramsis S. Girgis ,  Asim Fazlagic

    发明人： Nicolaie Laurentiu Fantana ,  Lars Pettersson ,  Mark D. Perkins ,  Ramsis S. Girgis ,  Asim Fazlagic

    IPC分类号： G06F15/00

    CPC分类号： G06Q10/06 ,  G06Q10/04 ,  G06Q10/10

    摘要： A method and system for the systematic evaluation and rating of technical equipment using a data processing device (20), which works together with at least one data memory (21) and has an input (22) and display device (23), in which, step-by-step for the particular technical equipment, at least one first data set having economically relevant input parameters and at least one second data set having technically relevant input parameters are detected and/or established. For each data set, through knowledge-based predetermined numerical and/or logical linkages and knowledge-based predetermined weighting factors specific to the equipment, the established input parameters are brought together into an economic evaluation parameter FIx and a technical evaluation parameter RIx, respectively, and from the established evaluation parameters, through knowledge-based predetermined numerical linkages and weighting factors, a single overall resulting evaluation parameter EIx is determined.

    摘要翻译： 一种用于使用与至少一个数据存储器（21）一起工作并具有输入（22）和显示设备（23）的数据处理设备（20）对技术设备进行系统评估和评级的方法和系统，其中 对于特定技术设备的分步骤，检测和/或建立具有经济上相关的输入参数的至少一个第一数据集和具有技术上相关的输入参数的至少一个第二数据集。 对于每个数据集，通过基于知识的预定数值和/或逻辑联系以及对设备特有的基于知识的预定加权因子，将建立的输入参数分别汇总成经济评估参数FIx和技术评估参数RIx， 并且通过基于知识的预定数值联系和加权因子从已建立的评估参数中确定单个总体得到的评估参数EIx。