公开(公告)号：US20130203703A1

公开(公告)日：2013-08-08

申请号：US13824256

申请日：2011-10-11

申请人： Lars Pettersson

发明人： Lars Pettersson

IPC分类号： C07D215/56 ,  C07F9/60 ,  C07D495/04

CPC分类号： C07D215/56 ,  C07D495/04 ,  C07F9/60

摘要： The present invention relates to compounds which are 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides, their thieno-pyridone analogs, and prodrugs thereof. This invention specifically relates to such derivatives containing an N-hydrogen in the carboxanilide moiety and which exhibit modulating activity towards the aromatic hydrocarbon receptor (AhR), and, specifically, also to prodrugs thereof. The present invention also relates to use of said compounds as a medicament, and for the treatment of cancer, autoimmune disorders and other disorders with an immunological component, and a pharmaceutical composition comprising one or more of said compounds and a method of treatment.

摘要翻译： 本发明涉及1,2-二氢-4-羟基-2-氧代喹啉-3-甲酰苯胺化合物，其噻吩并吡啶酮类似物及其前药。 本发明具体涉及在羧酰苯胺部分中含有N-氢的衍生物，其表现出对芳香族烃受体（AhR）的调节活性，特别涉及其前药。 本发明还涉及所述化合物作为药物以及用免疫组分治疗癌症，自身免疫疾病和其它病症以及包含一种或多种所述化合物和治疗方法的药物组合物的用途。

公开(公告)号：US08962598B2

公开(公告)日：2015-02-24

申请号：US13824256

申请日：2011-10-11

申请人： Lars Pettersson

发明人： Lars Pettersson

IPC分类号： A61K31/675 ,  C07D513/02 ,  C07D215/00 ,  C07D215/56 ,  C07D495/04 ,  C07F9/60

CPC分类号： C07D215/56 ,  C07D495/04 ,  C07F9/60

摘要： The present invention relates to compounds which are 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides, their thieno-pyridone analogs, and prodrugs thereof. This invention specifically relates to such derivatives containing an N-hydrogen in the carboxanilide moiety and which exhibit modulating activity towards the aromatic hydrocarbon receptor (AhR), and, specifically, also to prodrugs thereof. The present invention also relates to use of said compounds as a medicament, and for the treatment of cancer, autoimmune disorders and other disorders with an immunological component, and a pharmaceutical composition comprising one or more of said compounds and a method of treatment.

摘要翻译： 本发明涉及1,2-二氢-4-羟基-2-氧代喹啉-3-甲酰苯胺化合物，其噻吩并吡啶酮类似物及其前药。 本发明具体涉及在羧酰苯胺部分中含有N-氢的衍生物，其表现出对芳香族烃受体（AhR）的调节活性，特别涉及其前药。 本发明还涉及所述化合物作为药物以及用免疫组分治疗癌症，自身免疫疾病和其它病症以及包含一种或多种所述化合物和治疗方法的药物组合物的用途。