Invention Grant
- Patent Title: Selective glycosidase inhibitors and uses thereof
- Patent Title (中): 选择性糖苷酶抑制剂及其用途
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Application No.: US13591927Application Date: 2012-08-22
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Publication No.: US08962664B2Publication Date: 2015-02-24
- Inventor: David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
- Applicant: David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
- Applicant Address: CA Burnaby
- Assignee: Simon Fraser University
- Current Assignee: Simon Fraser University
- Current Assignee Address: CA Burnaby
- Agency: Clark & Elbing LLP
- Main IPC: A61K31/429
- IPC: A61K31/429 ; C07D513/04 ; G01N33/68 ; C07D513/14 ; C07F9/6561 ; C07H9/06
Abstract:
The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Public/Granted literature
- US20120316207A1 SELECTIVE GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2012-12-13
Information query
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