发明授权
- 专利标题: Heat shock protein GP96 vaccination and methods of using same
- 专利标题(中): 热休克蛋白GP96疫苗接种及使用方法
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申请号: US12933567申请日: 2009-03-19
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公开(公告)号: US08968720B2公开(公告)日: 2015-03-03
- 发明人: Eckhard R. Podack , Joseph R. Rosenblatt
- 申请人: Eckhard R. Podack , Joseph R. Rosenblatt
- 申请人地址: US FL Miami
- 专利权人: University of Miami
- 当前专利权人: University of Miami
- 当前专利权人地址: US FL Miami
- 代理机构: Fish & Richardson P.C.
- 国际申请: PCT/US2009/001727 WO 20090319
- 国际公布: WO2009/117116 WO 20090924
- 主分类号: A01N63/00
- IPC分类号: A01N63/00 ; A61K39/395 ; C12N15/63 ; A61K38/17 ; A61K39/00 ; C07K16/28 ; C12N5/16 ; A61K35/12
摘要:
The invention provides a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a heat shock protein (hsp) gp96 polypeptide. The invention also provides a method of stimulating an immune response to a tumor by administering a tumor cell genetically modified to express a nucleic acid encoding a secreted form of a gp96 polypeptide.