发明授权
US08980544B2 Boronic and borinic acid compounds as inhibitors of sulfenic acid-containing proteins
有权
硼酸和硼酸化合物作为含亚磺酸蛋白质的抑制剂
- 专利标题： Boronic and borinic acid compounds as inhibitors of sulfenic acid-containing proteins
- 专利标题（中）： 硼酸和硼酸化合物作为含亚磺酸蛋白质的抑制剂
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申请号： US14011308申请日： 2013-08-27
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公开(公告)号： US08980544B2公开(公告)日： 2015-03-17
- 发明人: Stephen Benkovic , Chunyu Liu , John W. Tomsho
- 申请人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
- 申请人地址： US PA University Park
- 专利权人： The Penn State Research Foundation
- 当前专利权人： The Penn State Research Foundation
- 当前专利权人地址： US PA University Park
- 代理机构： Husch Blackwell, LLP
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00 ; C12N9/99 ; C12N9/88
摘要：
A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of Formula I or a salt, hydrate or solvate thereof, whose components are disclosed within, and that contact is maintained for a time sufficient to inhibit the biological activity of the protein.
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