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公开(公告)号：US10160867B2
公开(公告)日：2018-12-25
申请号：US15227154
申请日：2016-08-03
摘要： A latex paint composition that contains a film-forming binder and pigment dispersed in an aqueous vehicle and also contains an effective amount of one or more cellulose-supportable fungus growth-inhibiting benzoxaborole compounds of Formula C is disclosed. A method of using that latex paint to inhibit the growth of a cellulose-supportable fungus on a cellulosic surface is also disclosed, as is a method of inhibiting such growth by painting over an fungus-infected surface with a contemplated latex paint.
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2.发明授权Boronic and borinic acid compound as inhibitors of sulfenic acid-containing proteins 有权硼酸和硼酸化合物作为含亚磺酸蛋白质的抑制剂公开(公告)号：US09309508B2
公开(公告)日：2016-04-12
申请号：US14576613
申请日：2014-12-19
申请人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
发明人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
CPC分类号： C12N9/99 , C12N9/88 , C12Y402/01084
摘要： A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of Formula I or a salt, hydrate or solvate thereof, whose components are disclosed within, and that contact is maintained for a time sufficient to inhibit the biological activity of the protein.
摘要翻译： 使用硼酸或硼酸化合物抑制含亚磺酸的蛋白质的活性。 因此，含有生物活性的含亚磺酸的蛋白质与活性抑制有效量的式I的硼酸或硼酸化合物或其盐，水合物或溶剂合物接触，其组分在其中公开，并且保持接触 足以抑制蛋白质的生物活性。
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公开(公告)号：US20160324160A1
公开(公告)日：2016-11-10
申请号：US15093331
申请日：2016-04-07
申请人： Stephen Benkovic , Chunyu Liu
发明人： Stephen Benkovic , Chunyu Liu
摘要： An anti-fungal composition for the control of one or more target fungi (or a similar heterotrophic, hyphae-producing organism) that infect plant materials and are (is) separately controllable by a benzoxaborole and an anti-fungal compound of a preselected FRAC Target Site Code is disclosed, as is a method of its use. A composition contains a diluent medium having dissolved or dispersed therein a synergistic effective amount of each of a first and a second anti-fungal compound. The first anti-fungal compound is a benzoxaborole of Formula I. The second anti-fungal compound is other than a benzoxaborole and is known to control said one or more target species of fungus when utilized as the sole anti-fungal compound at a concentration greater than the synergistic effective amount and has a preselected FRAC Target Site Code of B, C, D, E, G, H, or M.
摘要翻译： 用于控制感染植物材料的一种或多种目标真菌（或类似的异养，菌丝产生生物体）的抗真菌组合物，其可分别由预选的FRAC靶标的苯并恶唑和抗真菌化合物控制 公开了现场代码，以及其使用方法。 组合物含有溶解或分散有协同有效量的第一和第二抗真菌化合物的稀释介质。 第一种抗真菌化合物是式I的苯并恶唑。第二种抗真菌化合物是除苯并恶唑之外的化合物，当用作唯一的抗真菌化合物时，已知可以控制所述一种或多种目标物种的真菌浓度 具有协同有效量，并具有B，C，D，E，G，H或M的预先选定的FRAC目标位点代码。
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4.发明申请公开(公告)号：US20170037258A1
公开(公告)日：2017-02-09
申请号：US15227154
申请日：2016-08-03
IPC分类号： C09D5/14 , A01N55/08 , C09D121/02 , C07F5/04
CPC分类号： C09D5/14 , A01N55/08 , C07F5/04 , C08K5/0058 , C08K5/55 , C09D5/025 , C09D121/02 , A01N25/10
摘要： A latex paint composition that contains a film-forming binder and pigment dispersed in an aqueous vehicle and also contains an effective amount of one or more cellulose-supportable fungus growth-inhibiting benzoxaborole compounds of Formula C is disclosed. A method of using that latex paint to inhibit the growth of a cellulose-supportable fungus on a cellulosic surface is also disclosed, as is a method of inhibiting such growth by painting over an fungus-infected surface with a contemplated latex paint.
摘要翻译： 公开了含有分散在水性载体中的成膜粘合剂和颜料并且还含有有效量的一种或多种式C的可支持纤维素的真菌生长抑制性苯并恶唑化合物的乳胶漆组合物。 还公开了使用该乳胶漆来抑制纤维素可支持真菌在纤维素表面上的生长的方法，以及通过用预期的胶乳涂料在真菌感染的表面上涂覆来抑制这种生长的方法。
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5.发明申请公开(公告)号：US20100303813A1
公开(公告)日：2010-12-02
申请号：US12663335
申请日：2008-06-06
IPC分类号： A61K39/395 , C12Q1/68 , G01N33/564 , G01N33/68 , C40B40/08 , A61K31/60 , A61K38/13 , A61K31/7105 , A61P29/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： The present disclosure provides biomarkers that are predictive a subject's responsiveness or non-responsiveness to an anti-TNF therapy. The biomarkers, compositions, and methods described herein are useful in selecting appropriate treatment modalities (e.g., an anti-TNF therapy or a non-anti-TNF therapy) for a subject suffering from a disease such as an immune disorder.
摘要翻译： 本公开提供了预测受试者对抗TNF治疗的反应性或非反应性的生物标志物。 本文描述的生物标志物，组合物和方法可用于选择患有诸如免疫疾病的疾病的受试者的合适的治疗方式（例如抗TNF治疗或非抗TNF治疗）。
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6.发明授权Boronic and borinic acid compounds as inhibitors of sulfenic acid-containing proteins 有权硼酸和硼酸化合物作为含亚磺酸蛋白质的抑制剂公开(公告)号：US08980544B2
公开(公告)日：2015-03-17
申请号：US14011308
申请日：2013-08-27
申请人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
发明人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
CPC分类号： C12N9/99 , C12N9/88 , C12Y402/01084
摘要： A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of Formula I or a salt, hydrate or solvate thereof, whose components are disclosed within, and that contact is maintained for a time sufficient to inhibit the biological activity of the protein.
摘要翻译： 使用硼酸或硼酸化合物抑制含亚磺酸的蛋白质的活性。 因此，含有生物活性的含亚磺酸的蛋白质与活性抑制有效量的式I的硼酸或硼酸化合物或其盐，水合物或溶剂合物接触，其组分在其中公开，并且保持接触 足以抑制蛋白质的生物活性。
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公开(公告)号：US09737075B2
公开(公告)日：2017-08-22
申请号：US15093331
申请日：2016-04-07
申请人： Stephen Benkovic , Chunyu Liu
发明人： Stephen Benkovic , Chunyu Liu
摘要： An anti-fungal composition for the control of one or more target fungi (or a similar heterotrophic, hyphae-producing organism) that infect plant materials and are (is) separately controllable by a benzoxaborole and an anti-fungal compound of a preselected FRAC Target Site Code is disclosed, as is a method of its use. A composition contains a diluent medium having dissolved or dispersed therein a synergistic effective amount of each of a first and a second anti-fungal compound. The first anti-fungal compound is a benzoxaborole of Formula I. The second anti-fungal compound is other than a benzoxaborole and is known to control said one or more target species of fungus when utilized as the sole anti-fungal compound at a concentration greater than the synergistic effective amount and has a preselected FRAC Target Site Code of B, C, D, E, G, H, or M.
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8.发明申请Boronic and Borinic Acid Compound as Inhibitors of Sulfenic Acid-Containing Proteins 有权硼酸和硼酸化合物作为含有磺酸的蛋白质的抑制剂公开(公告)号：US20150140635A1
公开(公告)日：2015-05-21
申请号：US14576613
申请日：2014-12-19
申请人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
发明人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
IPC分类号： C12N9/99
CPC分类号： C12N9/99 , C12N9/88 , C12Y402/01084
摘要： A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of Formula I or a salt, hydrate or solvate thereof, whose components are disclosed within, and that contact is maintained for a time sufficient to inhibit the biological activity of the protein.
摘要翻译： 使用硼酸或硼酸化合物抑制含亚磺酸的蛋白质的活性。 因此，含有生物活性的含亚磺酸的蛋白质与活性抑制有效量的式I的硼酸或硼酸化合物或其盐，水合物或溶剂合物接触，其组分在其中公开，并且保持接触 足以抑制蛋白质的生物活性。
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9.发明申请Boronic and Borinic Acid Compounds as Inhibitors of Sulfenic Acid-Containing Proteins 有权硼酸和硼酸化合物作为含有磺酸的蛋白质的抑制剂公开(公告)号：US20140147905A1
公开(公告)日：2014-05-29
申请号：US14011308
申请日：2013-08-27
申请人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
发明人： Stephen Benkovic , Chunyu Liu , John W. Tomsho
IPC分类号： C12N9/99
CPC分类号： C12N9/99 , C12N9/88 , C12Y402/01084
摘要： A boronic or borinic acid compound is used to inhibit the activity of a sulfenic acid-containing protein. Thus, a biologically-active sulfenic acid-containing protein is contacted with an activity-inhibiting effective amount of a boronic or borinic acid compound of Formula I or a salt, hydrate or solvate thereof, whose components are disclosed within, and that contact is maintained for a time sufficient to inhibit the biological activity of the protein.
摘要翻译： 使用硼酸或硼酸化合物抑制含亚磺酸的蛋白质的活性。 因此，含有生物活性的含亚磺酸的蛋白质与活性抑制有效量的式I的硼酸或硼酸化合物或其盐，水合物或溶剂合物接触，其组分在其中公开，并且保持接触 足以抑制蛋白质的生物活性。
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