Invention Grant
- Patent Title: Site-specific incorporation of amino acids into molecules
- Patent Title (中): 位点特异性将氨基酸并入分子
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Application No.: US13969368Application Date: 2013-08-16
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Publication No.: US08980581B2Publication Date: 2015-03-17
- Inventor: Pin Wang , Inchan Kwon , Soojin Son , Yi Tang , David Tirrell
- Applicant: California Institute of Technology
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasadena
- Agency: Seed IP Law Group PLLC
- Main IPC: C12P21/02
- IPC: C12P21/02 ; G01N33/68 ; C12N9/00 ; C12N15/67 ; C12N15/70
Abstract:
The invention provides certain embodiments relating to methods and compositions for incorporating non-natural amino acids into a polypeptide or protein by utilizing a mutant or modified aminoacyl-tRNA synthetase to charge the non-natural amino acid to a the corresponding tRNA. In certain embodiments, the tRNA is also modified such that the complex forms strict Watson-Crick base-pairing with a codon that normally forms wobble base-pairing with unmodified tRNA/aminoacyl-tRNA synthetase pairs.
Public/Granted literature
- US20140045261A1 SITE-SPECIFIC INCORPORATION OF AMINO ACIDS INTO MOLECULES Public/Granted day:2014-02-13
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