发明授权
- 专利标题： Spirocyclic derivatives as histone deacetylase inhibitors
- 专利标题（中）： 螺环衍生物作为组蛋白脱乙酰酶抑制剂
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申请号： US13446861申请日： 2012-04-13
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公开(公告)号： US08980877B2公开(公告)日： 2015-03-17
- 发明人: Mario Varasi , Florian Thaler , Raffaella Amici , Agnese Abate , Maria Carmela Fulco , Saverio Minucci , Ciro Mercurio
- 申请人： Mario Varasi , Florian Thaler , Raffaella Amici , Agnese Abate , Maria Carmela Fulco , Saverio Minucci , Ciro Mercurio
- 申请人地址： IT Milan
- 专利权人： DAC S.R.L.
- 当前专利权人： DAC S.R.L.
- 当前专利权人地址： IT Milan
- 代理机构： McCormick, Paulding & Huber, LLP
- 优先权： EP08154528 20080415; EP09172856 20091013; WOPCT/EP2010/065176 20101011
- 主分类号： A61K31/407
- IPC分类号： A61K31/407 ; A61K31/438 ; A61K31/55 ; C07D491/107 ; A61K31/397 ; A61K31/537 ; C07D498/10
摘要：
This invention is related to new histone deacetylase inhibitors according to the general formula (I), wherein: m and n are independently zero or an integer from 1 to 4; p is zero or an integer from 1 to 3, with the proviso that when p is zero, n and m cannot be both 1; R is hydrogen; C1-C6 alkyl, optionally substituted by C3-C8 cycloalkyl, C6-C10 aryl or hetero(C2-C9)aryl; (CO)R2; (SO2)R3; C3-C8 cycloalkyl; C6-C10 aryl; or hetero(C2-C9)aryl; R1 is halogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy; Y is CH2 or NR4; Z is C═R5; and R2, R3, R4, and R5 are as further defined in the specification; and pharmaceutical acceptable salts thereof.