An electronic device may transmit and receive wireless signals using wireless circuitry that is controlled by control circuitry. The wireless circuitry may include adjustable components such as adjustable antenna structures, adjustable front end circuitry, and adjustable transceiver circuitry. During characterization operations, the electronic device may be tested to identify operating settings for the wireless circuitry that lead to potential wireless interference between aggressor transmitters and victim receivers. The control circuitry can adjust the wireless circuitry to mitigate the effects of interference based on settings identified during characterization operations or real time signal quality measurements.