Systems and methodologies are described herein that facilitate a synchronous bus architecture for multi-radio coexistence associated with a wireless device. As described herein, a system of buses operating in a synchronous manner, combined with optional on-chip and/or other supplemental buses, can be utilized to couple respective radios and/or other related endpoints to a coexistence management platform, thereby facilitating management of coexistence between multiple radios in a unified and scalable manner. As further described herein, communication between a coexistence manager and its respective managed endpoints can be facilitated through the use of a single bus or multiple buses (e.g., external buses, on-chip and/or other internal buses, etc.) that can operate concurrently and/or in an otherwise cooperative manner to facilitate expedited conveyance of radio event notifications and their corresponding responses.