Invention Grant
- Patent Title: Compounds that are ERK inhibitors
- Patent Title (中): ERK抑制剂的化合物
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Application No.: US13881050Application Date: 2011-10-24
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Publication No.: US08999966B2Publication Date: 2015-04-07
- Inventor: Sobhana Babu Boga , Joseph M. Kelly , Hugh Y. Zhu , Abdul-Basit Alhassan , Xin Yao , Xiaolei Gao , James J-S Wang , Jagdish A. Desai , Subrahmanyam Gudipati , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr.
- Applicant: Sobhana Babu Boga , Joseph M. Kelly , Hugh Y. Zhu , Abdul-Basit Alhassan , Xin Yao , Xiaolei Gao , James J-S Wang , Jagdish A. Desai , Subrahmanyam Gudipati , Sie-Mun Lo , Liang Zhu , Alan B. Cooper , Yongqi Deng , Gerald W. Shipps, Jr.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Richard S. Parr; Laura M. Ginkel
- International Application: PCT/US2011/057414 WO 20111024
- International Announcement: WO2012/058127 WO 20120503
- Main IPC: A61K31/397
- IPC: A61K31/397 ; A61K31/5377 ; A61K31/506 ; A61K31/4545 ; A61K31/454 ; A61K31/4523 ; A61K31/4427 ; A61K31/4439 ; A61K31/444 ; C07D413/14 ; C07D401/14 ; C07D403/14 ; C07D221/00 ; C07D221/02 ; C07D211/80 ; C07D405/14 ; C07D409/14 ; C07D417/14 ; C07D471/04 ; A61K45/06
Abstract:
Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocycloalkenyl ring, or a bridged monocyclic heterocycloalkyl ring, or a fused (monocyclic heterocycloalkyl ring) cyclopropyl ring. Also disclosed are methods of treating cancer using the compounds of formula (1).
Public/Granted literature
- US20130237518A1 NOVEL COMPOUNDS THAT ARE ERK INHIBITORS Public/Granted day:2013-09-12
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