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发明授权
US09000222B2 Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof 有权
（1E，6E）-1,7-双 - （3,4-二甲氧基苯基）-4,4-二取代 - 七-1,6-二烯-3,5-二酮结构支架的化合物，它们的生物活性和用途 其中

Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
摘要：
The present invention includes compounds, pharmaceuticals and cosmetics having at least one (substituted phenyl)-propenal moiety. The compounds and compositions of the present invention are useful in the treatment or prevention of medical conditions including androgen associated conditions, androgen associated inflammation, a wound (the compounds assist with wound healing), acne, rheumatoid arthritis, psoriasis, rosacea, and alopecia; Kennedy's disease (spinal and bulbar muscular atrophy, or SBMA), polyglutamine-mediated motor neuron degeneration; cancers such as prostate cancer, bladder cancer, breast cancer, ovarian cancer, hepatocellular (liver) cancer, and pancreatic cancer; and other medical conditions described herein. Treatment of such medical conditions includes administering to an individual suffering from a medical condition describe herein, a therapeutically effective amount of any of the disclosed compounds, their derivatives, or pharmaceutical compositions thereof.
摘要（中）：

本发明包括具有至少一个（取代的苯基） - 丙烯酸部分的化合物，药物和化妆品。 本发明的化合物和组合物可用于治疗或预防包括雄激素相关病症，雄激素相关炎症，伤口（辅助伤口愈合的化合物），痤疮，类风湿性关节炎，牛皮癣，酒渣鼻和脱发的医学病症; 肯尼迪病（脊髓和延髓肌肉萎缩或SBMA），聚谷氨酰胺介导的运动神经元变性; 癌症如前列腺癌，膀胱癌，乳腺癌，卵巢癌，肝细胞癌（肝癌）和胰腺癌; 和本文所述的其它医学病症。 治疗这样的医学病症包括对患有本文所述的医学病症的个体施用治疗有效量的任何所公开的化合物，其衍生物或其药物组合物。

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