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    Enhancement of anti-androgenic activity by a combination of inhibitors targeting different steps of a steroid-dependent gene activation pathway and uses thereof
    3.
    发明申请
    Enhancement of anti-androgenic activity by a combination of inhibitors targeting different steps of a steroid-dependent gene activation pathway and uses thereof 审中-公开
    通过针对类固醇依赖性基因激活途径的不同步骤的抑制剂的组合增强抗雄激素活性及其用途

    公开(公告)号：US20050209205A1

    公开(公告)日：2005-09-22

    申请号：US11045181

    申请日：2005-01-27

    申请人： Charles Shih ,  Ching-Yuan Su

    发明人： Charles Shih ,  Ching-Yuan Su

    IPC分类号： A61K31/12 ,  A61K31/56

    CPC分类号： A61K31/343 ,  A61K31/12 ,  A61K31/444 ,  A61K31/47 ,  A61K31/56 ,  A61K45/06 ,  G01N33/6872 ,  G01N33/743 ,  A61K2300/00

    摘要： The present invention includes novel methods and compositions for inhibiting or reducing steroid-dependent gene activation including the administration of at least two compounds that act different steps within a steroid receptor gene activation pathway. Preferred methods may include administering a first compound able to induce degradation of a steroid receptor and administering a second compound able to inhibit gene activation at a different step of the steroid receptor pathway. Steroid-dependent gene activation may be reduced or inhibited, modulated or controlled greater when the at least two of the compounds are administered in combination or together.

    摘要翻译： 本发明包括用于抑制或减少类固醇依赖性基因激活的新方法和组合物，包括施用至少两种在类固醇受体基因激活途径内起作用不同步骤的化合物。 优选的方法可以包括施用能够诱导类固醇受体降解的第一化合物和施用能够在类固醇受体途径的不同步骤抑制基因激活的第二化合物。 当组合或一起施用至少两种化合物时，类固醇依赖性基因激活可以减少或抑制，调节或控制更大。

    Methods and compositions for enhancing degradation of nuclear receptor transcription factors and uses thereof
    4.
    发明申请
    Methods and compositions for enhancing degradation of nuclear receptor transcription factors and uses thereof 审中-公开
    用于增强核受体转录因子降解的方法和组合物及其用途

    公开(公告)号：US20060084704A1

    公开(公告)日：2006-04-20

    申请号：US11218889

    申请日：2005-09-02

    申请人： Charles Shih ,  Ching-Yuan Su

    发明人： Charles Shih ,  Ching-Yuan Su

    IPC分类号： A61K9/127 ,  A61K31/12

    CPC分类号： A61K31/12 ,  A61K8/35 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/06 ,  A61Q19/00

    摘要： The present invention includes methods, compositions, cosmetics and pharmaceutical compositions for enhancing the degradation of a nuclear receptor (NR) or a STAT transcription factor protein. The methods, compositions, cosmetics and pharmaceuticals may be used to prevent or treat disorders or medical conditions that are at least in part affected by a nuclear receptor activation pathway or STAT activation pathway.

    摘要翻译： 本发明包括用于增强核受体（NR）或STAT转录因子蛋白质降解的方法，组合物，化妆品和药物组合物。 方法，组合物，化妆品和药物可用于预防或治疗至少部分受核受体活化途径或STAT活化途径影响的病症或医学病症。