发明授权
US09045440B2 Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents
有权
脱氮铁硫蛋白和脱氮铁硫蛋白聚醚类似物作为金属螯合剂
- 专利标题： Desazadesferrothiocin and desazadesferrothiocin polyether analogues as metal chelation agents
- 专利标题（中）： 脱氮铁硫蛋白和脱氮铁硫蛋白聚醚类似物作为金属螯合剂
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申请号： US13100705申请日： 2011-05-04
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公开(公告)号： US09045440B2公开(公告)日： 2015-06-02
- 发明人: James Malecha
- 申请人： James Malecha
- 申请人地址： US PA Wayne
- 专利权人： FerroKin Biosciences, Inc.
- 当前专利权人： FerroKin Biosciences, Inc.
- 当前专利权人地址： US PA Wayne
- 代理机构： Choate, Hall & Stewart, LLP
- 代理商 Fangli Chen; John P. Rearick
- 主分类号： C07D231/14
- IPC分类号： C07D231/14 ; C07D233/28 ; C07D263/16 ; C07D277/12 ; C07D277/56 ; A61K31/5377 ; A61K31/421 ; A61K31/4172 ; A61K31/426 ; A61K31/496
摘要：
Disclosed herein are new compounds of desazadesferrothiocin polyether (DADFT-PE) analogs, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.