An exemplary optical computing device includes an electromagnetic radiation source that optically interacts with a sample having a characteristic of interest, a first integrated computational element arranged within a primary channel to optically interact with the electromagnetic radiation source and produce a first modified electromagnetic radiation, wherein the first integrated computational element is configured to be positively or negatively correlated to the characteristic of interest, a second integrated computational element arranged within a reference channel to optically interact with the electromagnetic radiation source and produce a second modified electromagnetic radiation, wherein the second integrated computational element is configured to correlated to the characteristic of interest with an opposite sign relative to the first integrated computational element, and a first detector arranged to generate a first signal from the first modified electromagnetic radiation and a second signal from the second modified electromagnetic radiation.