Invention Grant
US09079918B2 Macrocycles as factor XIa inhibitors 有权
大环作为因子XIa抑制剂

Macrocycles as factor XIa inhibitors
Abstract:
The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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