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公开(公告)号：US20160362414A1
公开(公告)日：2016-12-15
申请号：US15246813
申请日：2016-08-25
Applicant: Bristol-Myers Squibb Company
Inventor： Mimi L. Quan , Carl P. Decicco , James R. Corte , Cailan Wang
IPC: C07D487/04 , C07D487/14 , C07D471/14 , C07D498/04
CPC classification number: C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Abstract translation: 或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或fXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US09079918B2
公开(公告)日：2015-07-14
申请号：US14448058
申请日：2014-07-31
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Mimi L. Quan , Carl P. Decicco , James R. Corte , Cailan Wang
IPC: C07D487/06 , C07D487/08 , C07D471/08 , C07D471/18 , C07D498/08
CPC classification number: C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Abstract translation: 本发明提供式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或fXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US20150112058A1
公开(公告)日：2015-04-23
申请号：US14578846
申请日：2014-12-22
Applicant: Bristol-Myers Squibb Company
Inventor： James R. Corte , Tianan Fang , Carl P. Decicco , Donald J.P. Pinto , Karen A. Rossi , Zilun Hu , Yoon Jeon , Mimi L. Quan , Joanne M. Smallheer , Yufeng Wang , Wu Yang
IPC: C07D498/06 , C07D487/16 , C07D487/06
CPC classification number: C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Abstract translation: 本发明提供式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或fXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US20180022753A1
公开(公告)日：2018-01-25
申请号：US15718431
申请日：2017-09-28
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James R. Corte , Tianan Fang , Carl P. Decicco , Donald J.P. Pinto , Karen A. Rossi , Zilun Hu , Yoon Jeon , Mimi L. Quan , Joanne M. Smallheer , Yufeng Wang , Wu Yang
IPC: C07D487/04 , C07D487/14 , C07D471/14 , C07D487/18 , C07D471/18 , C07D498/06 , C07D487/16 , C07D487/06 , C07D498/08 , C07D498/04 , C07D487/08
CPC classification number: C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US20150266894A1
公开(公告)日：2015-09-24
申请号：US14733996
申请日：2015-06-09
Applicant: Bristol-Myers Squibb Company
Inventor： Mimi L. Quan , Carl P. Decicco , James R. Corte , Cailan Wang
IPC: C07D498/08 , C07D487/18 , C07D471/18 , C07D487/08
CPC classification number: C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Abstract translation: 本发明提供式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或fXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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Patent Agency Ranking
公开(公告)号：US20140343276A1
公开(公告)日：2014-11-20
申请号：US14448058
申请日：2014-07-31
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Mimi L. Quan , Carl P. Decicco , James R. Corte , Cailan Wang
IPC: C07D498/08 , C07D487/08
CPC classification number: C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
Abstract translation: 本发明提供式（I）的化合物或其立体异构体，互变异构体或其药学上可接受的盐，其中所有变量如本文所定义。 这些化合物是选择性因子XIa抑制剂或fXIa和血浆激肽释放酶的双重抑制剂。 本发明还涉及包含这些化合物的药物组合物和使用其制备血栓栓塞和/或炎症性疾病的方法。
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公开(公告)号：US11136327B2
公开(公告)日：2021-10-05
申请号：US16691099
申请日：2019-11-21
Applicant: Bristol-Myers Squibb Company
Inventor： James R. Corte , Tianan Fang , Carl P. Decicco , Donald J. P. Pinto , Karen A. Rossi , Zilun Hu , Yoon Jeon , Mimi L. Quan , Joanne M. Smallheer , Yufeng Wang , Wu Yang
IPC: C07D487/04 , C07D487/08 , C07D498/08 , C07D487/06 , C07D487/16 , C07D498/06 , C07D471/18 , C07D487/18 , C07D471/14 , C07D487/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US09802939B2
公开(公告)日：2017-10-31
申请号：US14578846
申请日：2014-12-22
Applicant: Bristol-Myers Squibb Company
Inventor： James R. Corte , Tianan Fang , Carl P. Decicco , Donald J. P. Pinto , Karen A. Rossi , Zilun Hu , Yoon Jeon , Mimi L. Quan , Joanne M. Smallheer , Yufeng Wang , Wu Yang
IPC: C07D487/18 , C07D487/04 , C07D487/08 , C07D498/08 , C07D487/06 , C07D487/16 , C07D498/06 , C07D471/18 , C07D471/14 , C07D487/14 , C07D498/04
CPC classification number: C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US09745313B2
公开(公告)日：2017-08-29
申请号：US15246813
申请日：2016-08-25
Applicant: Bristol-Myers Squibb Company
Inventor： Mimi L. Quan , Carl P. Decicco , James R. Corte , Cailan Wang
IPC: C07D487/18 , C07D487/04 , C07D487/08 , C07D498/08 , C07D487/06 , C07D487/16 , C07D498/06 , C07D471/18 , C07D471/14 , C07D487/14 , C07D498/04
CPC classification number: C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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公开(公告)号：US09453029B2
公开(公告)日：2016-09-27
申请号：US14733996
申请日：2015-06-09
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Mimi L. Quan , Carl P. Decicco , James R. Corte , Cailan Wang
IPC: C07D487/06 , C07D498/06 , C07D471/08 , C07D471/18 , C07D487/08 , C07D487/18 , C07D498/08 , C07D487/16
CPC classification number: C07D487/04 , C07D471/14 , C07D471/18 , C07D487/06 , C07D487/08 , C07D487/14 , C07D487/16 , C07D487/18 , C07D498/04 , C07D498/06 , C07D498/08
Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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