发明授权
US09085538B2 Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
有权
制备用于合成他汀类药物或其药学上可接受的盐的关键中间体的方法
- 专利标题： Process for the preparation of key intermediates for the synthesis of statins or pharmaceutically acceptable salts thereof
- 专利标题（中）： 制备用于合成他汀类药物或其药学上可接受的盐的关键中间体的方法
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申请号： US13812458申请日： 2011-07-25
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公开(公告)号： US09085538B2公开(公告)日： 2015-07-21
- 发明人: Zdenko Casar , Damjan Sterk , Marko Jukic
- 申请人： Zdenko Casar , Damjan Sterk , Marko Jukic
- 申请人地址： SI Ljubljana
- 专利权人： LEK PHARMACEUTICALS D.D.
- 当前专利权人： LEK PHARMACEUTICALS D.D.
- 当前专利权人地址： SI Ljubljana
- 代理机构： Arent Fox LLP
- 优先权： EP10170739 20100726
- 国际申请： PCT/EP2011/003714 WO 20110725
- 国际公布： WO2012/013325 WO 20120202
- 主分类号： C07D239/12
- IPC分类号： C07D239/12 ; C07D239/42 ; C07C45/68 ; C07C49/807 ; C07D215/14 ; C07D239/46 ; C07C49/86 ; C07D215/12
摘要：
The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.