Invention Grant
US09086416B2 Removable saccharide-benzimidazole (BIM) tags and conjugates thereof via 1H-position of the benzimidazoles
有权
可移动的糖 - 苯并咪唑(BIM)标签及其通过苯并咪唑的1H位的共轭物
- Patent Title: Removable saccharide-benzimidazole (BIM) tags and conjugates thereof via 1H-position of the benzimidazoles
- Patent Title (中): 可移动的糖 - 苯并咪唑(BIM)标签及其通过苯并咪唑的1H位的共轭物
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Application No.: US13548181Application Date: 2012-07-12
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Publication No.: US09086416B2Publication Date: 2015-07-21
- Inventor: Wen-Bin Yang
- Applicant: Wen-Bin Yang
- Applicant Address: TW Taipei
- Assignee: Academia Sinica
- Current Assignee: Academia Sinica
- Current Assignee Address: TW Taipei
- Agency: Eckman Basu LLP
- Agent Shantanu Basu
- Main IPC: A61K31/70
- IPC: A61K31/70 ; A61K31/7028 ; A61K31/7042 ; C07H15/00 ; C07H15/04 ; C07H17/00 ; G01N33/58 ; C07H15/26 ; G01N33/531

Abstract:
Novel method and reagents for generating reversibly tagged saccharides, aldehydes, carboxyl acids, or orthoacetates useful in analytical and diagnostic applications are disclosed. Saccharides are coupled at the reducing end to tagging moieties comprising a reagent selected from a ortho-diaminobenzoic (DAB)-peptide, an aldo-imidazole or N-methylated aldo-imidazole, or an ortho-phenyldiamine (OPD) or substituted OPD. The tagged saccharide further comprising detectable or functional groups coupled to the tagging moiety are provided. Kits and reagents for chromatography and mass spectrometry are disclosed.
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