Glycosylation of exo-glycals
    4.
    发明授权
    Glycosylation of exo-glycals 失效
    外切糖的糖基化

    公开(公告)号:US07078520B2

    公开(公告)日:2006-07-18

    申请号:US10406979

    申请日:2003-04-04

    CPC classification number: C07H1/00

    Abstract: This invention relates to a method of preparing a first alicyclic compound having a vinyl group on one alkyl ring carbon and an alkoxy, cycloalkoxy, heterocycloalkyoxy, aryloxy, or heteroaryloxy group on the same ring carbon; the method comprising reacting an aliphatic alcohol or an aromatic alcohol with a second alicyclic compound having an exo cyclic carbon-carbon double bond, wherein the non-ring olefinic carbon is substituted with a hydroxymethyl, thiomethyl, alkoxymethyl, aryloxymethyl, acyloxymethyl, alkylsulfonyloxymethyl, arylsulfonyloxymethyl, alkylsulfonylmethyl, arylsulfonylmethyl, halomethyl, or silyloxymethyl group.

    Abstract translation: 本发明涉及一种在同一环碳上一烷基环碳和烷氧基,环烷氧基,杂环烷氧基,芳氧基或杂芳氧基上具有乙烯基的第一脂环族化合物的制备方法; 所述方法包括使脂族醇或芳族醇与具有外环碳 - 碳双键的第二脂环族化合物反应,其中所述非环烯烃被羟甲基,硫代甲基,烷氧基甲基,芳氧基甲基,酰氧基甲基,烷基磺酰氧基甲基,芳基磺酰氧基甲基 ,烷基磺酰基甲基,芳基磺酰基甲基,卤代甲基或甲硅烷氧基甲基。

    Removable saccharide-benzimidazole (BIM) tags and conjugates thereof via 1H-position of the benzimidazoles
    5.
    发明授权
    Removable saccharide-benzimidazole (BIM) tags and conjugates thereof via 1H-position of the benzimidazoles 有权
    可移动的糖 - 苯并咪唑(BIM)标签及其通过苯并咪唑的1H位的共轭物

    公开(公告)号:US09086416B2

    公开(公告)日:2015-07-21

    申请号:US13548181

    申请日:2012-07-12

    Applicant: Wen-Bin Yang

    Inventor: Wen-Bin Yang

    CPC classification number: G01N33/58 C07H15/26 G01N33/531 Y10T436/14

    Abstract: Novel method and reagents for generating reversibly tagged saccharides, aldehydes, carboxyl acids, or orthoacetates useful in analytical and diagnostic applications are disclosed. Saccharides are coupled at the reducing end to tagging moieties comprising a reagent selected from a ortho-diaminobenzoic (DAB)-peptide, an aldo-imidazole or N-methylated aldo-imidazole, or an ortho-phenyldiamine (OPD) or substituted OPD. The tagged saccharide further comprising detectable or functional groups coupled to the tagging moiety are provided. Kits and reagents for chromatography and mass spectrometry are disclosed.

    Abstract translation: 公开了用于生成可用于分析和诊断应用的可逆标记的糖,醛,羧酸或原乙酸盐的新方法和试剂。 糖在还原端耦合到包含选自邻二氨基苯甲酸(DAB)肽,醛 - 咪唑或N-甲基化的醛 - 咪唑或邻苯基二胺(OPD)或取代的OPD的试剂的标记部分。 提供了进一步包含与标记部分偶联的可检测或官能团的标记糖。 公开了用于色谱和质谱的试剂盒和试剂。

    Reishi F3 sub fraction polysaccharides and methods of using same
    6.
    发明授权
    Reishi F3 sub fraction polysaccharides and methods of using same 有权
    Reishi F3分级多糖及其使用方法

    公开(公告)号:US08071105B2

    公开(公告)日:2011-12-06

    申请号:US12244709

    申请日:2008-10-02

    CPC classification number: A61K39/0002 A61K2039/55588

    Abstract: The present disclosure relates to the discovery of methods of isolating subfractions of an F3 Reishi extract, and of administration of these novel isolates to eukaryotic cells in order to induce certain immumodulatory, hematopoeitic and tumor-inhibiting phenotypic changes in those eukaryotic cells, mediated through particular toll-like receptor (TLR) and other transmembrane receptors. F3 subfractions F301 and F331 have demonstrated that F331 is capable of activating at least TLR-2 while F301 is capable of activating at least TLR-2, TLR-4, and TLR-5.

    Abstract translation: 本公开涉及发现分离F3赖氏提取物的亚组分的方法,以及将这些新型分离物施用于真核细胞,以便诱导那些通过特异性介导的那些真核细胞中的某些免疫调节,造血细胞和肿瘤抑制表型变化 toll样受体(TLR)和其他跨膜受体。 F3亚分数F301和F331已经证明F331能够至少激活至少TLR-2,而F301能够至少激活TLR-2,TLR-4和TLR-5。

    LENS AND FABRICATION METHOD THEREOF
    7.
    发明申请
    LENS AND FABRICATION METHOD THEREOF 审中-公开
    镜片及其制造方法

    公开(公告)号:US20120147477A1

    公开(公告)日:2012-06-14

    申请号:US13032703

    申请日:2011-02-23

    CPC classification number: G02B3/08 B29D11/0073 F24S23/30 Y02E10/40

    Abstract: A lens includes a glass substrate, and a silicone layer adhered to the glass substrate and having a pattern formed on an outer surface thereof. Since the light-transmissive silicone layer is directly adhered to the glass substrate, without the use of an adhesive layer, the fabrication cost and thickness of the lens are reduced, and the objective of thinning the lens is achieved.

    Abstract translation: 透镜包括玻璃基板和粘附到玻璃基板并且具有形成在其外表面上的图案的硅树脂层。 由于透光硅树脂层直接粘附到玻璃基板上,而不使用粘合剂层,所以减小了透镜的制造成本和厚度,并且实现了使透镜变薄的目的。

    Fungal immunostimulatory compositions
    9.
    发明申请
    Fungal immunostimulatory compositions 有权
    真菌免疫刺激成分

    公开(公告)号:US20070231339A1

    公开(公告)日:2007-10-04

    申请号:US11549215

    申请日:2006-10-13

    Abstract: Methods are disclosed which are useful in increasing maturation of dendritic cells from CD14+ mononuclear cells, by contact with a composition comprising a fucose-containing glycoprotein fraction from Ganoderma lucidum. The extract can also be used for increasing production of a cytokine or a chemokine in a dendritic cell or CD19+ B cell. In addition, a fucose-containing glycoprotein fraction from Ganoderma lucidum can be administered to a subject identified as needing increased immunoglobulin, cytokine, or chemokine production.

    Abstract translation: 通过与含有来自灵芝的含岩藻糖的糖蛋白部分的组合物的接触,公开了可用于从CD14 + +单核细胞增加树突状细胞成熟的方法。 提取物也可用于增加树突状细胞或CD19 + B细胞中细胞因子或趋化因子的产生。 此外,来自灵芝的含岩藻糖的糖蛋白部分可以施用于被鉴定为需要增加的免疫球蛋白,细胞因子或趋化因子产生的受试者。

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