发明授权
US09109014B2 Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom
有权
口蹄疫病毒（FMDV）共有蛋白质，其编码序列和由其制备的疫苗
- 专利标题： Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom
- 专利标题（中）： 口蹄疫病毒（FMDV）共有蛋白质，其编码序列和由其制备的疫苗
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申请号： US13503828申请日： 2010-11-02
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公开(公告)号： US09109014B2公开(公告)日： 2015-08-18
- 发明人: David B Weiner , Bernadette Ferraro , Jian Yan , Patricia A Brown , Rodney A Bowling , Douglas R Kern , Mathura P Ramanathan , Niranjan Y Sardesai , Karuppiah Muthumani
- 申请人： David B Weiner , Bernadette Ferraro , Jian Yan , Patricia A Brown , Rodney A Bowling , Douglas R Kern , Mathura P Ramanathan , Niranjan Y Sardesai , Karuppiah Muthumani
- 申请人地址： US PA Philadelphia US PA Plymouth Meeting
- 专利权人： The Trustees of the University of Pennsylvania,Inovio Pharmaceuticals, Inc.
- 当前专利权人： The Trustees of the University of Pennsylvania,Inovio Pharmaceuticals, Inc.
- 当前专利权人地址： US PA Philadelphia US PA Plymouth Meeting
- 代理机构： Riverside Law LLP
- 国际申请： PCT/US2010/055187 WO 20101102
- 国际公布： WO2011/054011 WO 20110505
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C07K14/005 ; A61K39/135 ; A61K39/00
摘要：
Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.