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1.发明授权Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom 有权口蹄疫病毒（FMDV）共有蛋白质，其编码序列和由其制备的疫苗公开(公告)号：US09109014B2
公开(公告)日：2015-08-18
申请号：US13503828
申请日：2010-11-02
申请人： David B Weiner , Bernadette Ferraro , Jian Yan , Patricia A Brown , Rodney A Bowling , Douglas R Kern , Mathura P Ramanathan , Niranjan Y Sardesai , Karuppiah Muthumani
发明人： David B Weiner , Bernadette Ferraro , Jian Yan , Patricia A Brown , Rodney A Bowling , Douglas R Kern , Mathura P Ramanathan , Niranjan Y Sardesai , Karuppiah Muthumani
IPC分类号： A61K39/12 , C07K14/005 , A61K39/135 , A61K39/00
CPC分类号： C07K14/005 , A61K39/12 , A61K39/135 , A61K39/39 , A61K2039/523 , A61K2039/53 , A61K2039/552 , A61M37/00 , A61N1/327 , C12N7/00 , C12N2770/32122 , C12N2770/32134 , G01N33/56983 , G01N2333/09 , G01N2469/20
摘要： Provided herein is a nucleic acid comprising consensus amino acid sequence of foot-and-mouth disease FMDV VP1-4 coat proteins of FMDV subtypes A, Asia 1, C, O, SAT1, SAT2, and SAT3 as well as plasmids and vaccines expressing the sequences. Also provided herein is methods for generating an immune response against one or more FMDV subtypes using the vaccine as described above as well as methods for deciphering between vaccinated mammals with the vaccine and those that are infected with FMDV.
摘要翻译： 本文提供的是包含FMDV亚型A，亚洲1，C，O，SAT1，SAT2和SAT3的口蹄疫FMDV VP1-4外壳蛋白的共有氨基酸序列的核酸，以及表达 序列。 本文还提供了使用上述疫苗产生针对一种或多种FMDV亚型的免疫应答的方法以及用疫苗接种的哺乳动物和用FMDV感染的哺乳动物之间进行解密的方法。
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2.发明授权Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same 有权共识的前列腺抗原，编码相同的核酸分子和疫苗以及包含它们的用途公开(公告)号：US08927692B2
公开(公告)日：2015-01-06
申请号：US13883978
申请日：2011-11-14
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/53 , C07K14/4748 , C12N9/485 , C12N9/6424 , C12Y116/01 , C12Y304/17021 , C12Y304/21077
摘要： Provided herein are consensus amino acid sequences of prostate antigens that are capable of breaking tolerance in a targeted species, including PSA, PSMA, STEAP and PSCA antigens. Also provided are nucleic acid sequences that encode one or more consensus amino acid sequences of prostate antigens PSA, PSMA, STEAP and PSCA, as well genetic constructs/vectors and vaccines expressing the sequences. Also provided herein are methods for generating an autoimmune response against prostate cancer cells by administering one or more of the vaccines, proteins, and/or nucleic acid sequences that are provided.
摘要翻译： 本文提供了能够在目标物种（包括PSA，PSMA，STEAP和PSCA抗原）中破坏耐受性的前列腺抗原的共有氨基酸序列。 还提供编码前列腺抗原PSA，PSMA，STEAP和PSCA的一个或多个共有氨基酸序列的核酸序列，以及表达序列的遗传构建体/载体和疫苗。 本文还提供了通过施用提供的一种或多种疫苗，蛋白质和/或核酸序列来产生针对前列腺癌细胞的自身免疫应答的方法。
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公开(公告)号：US20100291144A1
公开(公告)日：2010-11-18
申请号：US12812268
申请日：2009-01-12
IPC分类号： A61K39/21 , A61K39/12 , A61K39/145 , C12N15/63
CPC分类号： A61K39/12 , A61K2039/53 , A61K2039/54 , C07K14/005 , C12N2770/24122 , C12N2770/24134 , Y02A50/386 , Y02A50/394
摘要： An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal.
摘要翻译： 本发明的一个方面涉及能够表达在哺乳动物中针对多于一种登革热病毒亚型引起免疫应答的多肽的核酸构建体及其使用方法。 此外，存在能够在哺乳动物中产生针对多种登革热病毒亚型的免疫应答的DNA质粒疫苗，其包含DNA质粒和药学上可接受的赋形剂及其使用方法。 DNA质粒能够以有效引发哺乳动物免疫应答的量在哺乳动物细胞中表达一致性登革热抗原。
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