发明授权
US09109043B2 Screening method for antidiabetic agent using newly identified insulin secretion regulation factor
有权
使用新确定的胰岛素分泌调节因子的抗糖尿病药的筛选方法
- 专利标题： Screening method for antidiabetic agent using newly identified insulin secretion regulation factor
- 专利标题（中）： 使用新确定的胰岛素分泌调节因子的抗糖尿病药的筛选方法
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申请号： US13819809申请日： 2011-09-02
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公开(公告)号： US09109043B2公开(公告)日： 2015-08-18
- 发明人: Takeshi Imai , Hiroshi Handa
- 申请人： Takeshi Imai , Hiroshi Handa
- 申请人地址： JP Tokyo
- 专利权人： Tokyo Institute of Technology
- 当前专利权人： Tokyo Institute of Technology
- 当前专利权人地址： JP Tokyo
- 代理机构： Fredrikson & Byron, P.A.
- 优先权： JP2010-196952 20100902
- 国际申请： PCT/JP2011/070067 WO 20110902
- 国际公布： WO2012/029958 WO 20120308
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; A61K38/45 ; A61K38/16 ; A01K67/027
摘要：
It is an object of the present invention to provide a newly identified insulin secretion regulation factor that can control blood sugar in the normal range, and a method for screening an antidiabetic drug using said factor.In accordance with the present invention, there is provided a composition which is (i) a protein comprising an amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4; or (ii) a protein comprising an amino acid sequence in which one or several amino acids are deleted, substituted or added in an amino acid sequence represented by SEQ ID NO: 2 or SEQ ID NO: 4 and negatively regulating insulin secretion, as well as a method for screening antidiabetic drug using said protein or a nucleic acid encoding the same.
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