发明授权
US09114177B2 Block copolymer having phenylboronic acid group introduced therein, and use thereof
有权
其中引入苯基硼酸基的嵌段共聚物及其用途
- 专利标题： Block copolymer having phenylboronic acid group introduced therein, and use thereof
- 专利标题（中）： 其中引入苯基硼酸基的嵌段共聚物及其用途
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申请号： US14358816申请日： 2012-11-19
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公开(公告)号： US09114177B2公开(公告)日： 2015-08-25
- 发明人: Kazunori Kataoka , Takehiko Ishii , Mitsuru Naito , Akira Matsumoto , Yasuki Kato
- 申请人： THE UNIVERSITY OF TOKYO , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY , NanoCarrier Co., Ltd.
- 申请人地址： JP Tokyo JP Tokyo JP Kashiwa
- 专利权人： THE UNIVERSITY OF TOKYO,NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY,NANOCARRIER CO., LTD.
- 当前专利权人： THE UNIVERSITY OF TOKYO,NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY,NANOCARRIER CO., LTD.
- 当前专利权人地址： JP Tokyo JP Tokyo JP Kashiwa
- 代理机构： J-Tek Law PLLC
- 代理商 Jeffrey D. Tekanic; Scott T. Wakeman
- 国际申请： PCT/JP2012/079897 WO 20121119
- 国际公布： WO2013/073697 WO 20130523
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; A61K47/48 ; C08G81/00 ; C08G69/40 ; C08G69/42
摘要：
A block copolymer includes a polyamino acid chain segment and a hydrophilic polymer chain segment. The polyamino acid chain segment includes at least one amino acid residue having a side chain that contains a cationic group and at least one amino acid residue having a side chain that contains a substituted phenylboronic acid group. In the substituted phenylboronic acid group, at least one hydrogen of the phenyl ring is substituted so that the phenylboronic acid group has a pKa of less than 8. Such a block copolymer serves as a carrier that simultaneously imparts stability to a biotechnology-based drug in blood and provides suitable drug-releasing properties of the drug at an affected area.
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