发明授权
- 专利标题: Combined measles-malaria vaccine
- 专利标题(中): 麻疹联合麻疹疫苗
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申请号: US13318701申请日: 2010-05-03
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公开(公告)号: US09119815B2公开(公告)日: 2015-09-01
- 发明人: Reinhard Glueck , Agata Fazio , Viviana Giannino , Martin A Billeter
- 申请人: Reinhard Glueck , Agata Fazio , Viviana Giannino , Martin A Billeter
- 申请人地址: IN Ahmedabad
- 专利权人: CADILA HEALTHCARE LIMITED
- 当前专利权人: CADILA HEALTHCARE LIMITED
- 当前专利权人地址: IN Ahmedabad
- 代理机构: Ladas & Parry LLP
- 优先权: IN1181/MUM/2009 20090505
- 国际申请: PCT/IN2010/000287 WO 20100503
- 国际公布: WO2010/128524 WO 20101111
- 主分类号: C12N15/00
- IPC分类号: C12N15/00 ; A61K39/165 ; A61K39/015 ; A61K38/20 ; C12N7/00 ; A61K35/13 ; A61K39/00
摘要:
A combined measles-malaria vaccine containing different attenuated recombinant measles-malaria vectors comprising a heterologous nucleic acid encoding several Plasmodium falciparum antigens is described. Preferably, it relates to viral vectors that comprise nucleic acids encoding the circumsporozoite (CS) protein of P. falciparum, the merozoite surface protein 1 (MSP-1) of P. falciparum, and its derivatives (p-42; p-83-30-38) in its glycosylated and secreted forms, and apical membrane antigen1 (AMA1) of P. falciparum, in its anchored or secreted form. The viral vector stems from an attenuated measles virus, based on a strain that is used as a vaccine and is efficient in delivering the gene of interest and that binds to and infects the relevant immune cells efficiently.
公开/授权文献
- US20120121538A1 COMBINED MEASLES-MALARIA VACCINE 公开/授权日:2012-05-17
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