公开(公告)号：US09119815B2

公开(公告)日：2015-09-01

申请号：US13318701

申请日：2010-05-03

申请人： Reinhard Glueck ,  Agata Fazio ,  Viviana Giannino ,  Martin A Billeter

发明人： Reinhard Glueck ,  Agata Fazio ,  Viviana Giannino ,  Martin A Billeter

IPC分类号： C12N15/00 ,  A61K39/165 ,  A61K39/015 ,  A61K38/20 ,  C12N7/00 ,  A61K35/13 ,  A61K39/00

CPC分类号： A61K39/165 ,  A61K35/13 ,  A61K38/2013 ,  A61K39/0015 ,  A61K39/015 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55566 ,  A61K2039/55588 ,  A61K2039/575 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/18421 ,  C12N2760/18434 ,  C12N2760/18442 ,  C12N2760/18443 ,  Y02A50/412

摘要： A combined measles-malaria vaccine containing different attenuated recombinant measles-malaria vectors comprising a heterologous nucleic acid encoding several Plasmodium falciparum antigens is described. Preferably, it relates to viral vectors that comprise nucleic acids encoding the circumsporozoite (CS) protein of P. falciparum, the merozoite surface protein 1 (MSP-1) of P. falciparum, and its derivatives (p-42; p-83-30-38) in its glycosylated and secreted forms, and apical membrane antigen1 (AMA1) of P. falciparum, in its anchored or secreted form. The viral vector stems from an attenuated measles virus, based on a strain that is used as a vaccine and is efficient in delivering the gene of interest and that binds to and infects the relevant immune cells efficiently.

摘要翻译： 描述了包含编码几种恶性疟原虫抗原的异源核酸的包含不同的减毒重组麻疹 - 疟疾载体的麻疹 - 疟疾综合疫苗。 优选地，其涉及包含编码恶性疟原虫的环子孢子（CS）蛋白，恶性疟原虫的裂殖子表面蛋白1（MSP-1）及其衍生物（p-42; p-83- 30-38）以其糖基化和分泌形式，以及恶性疟原虫的顶端膜抗原1（AMA1）以其锚定或分泌形式。 病毒载体源自减毒的麻疹病毒，其基于用作疫苗的菌株，并且有效地传递感兴趣的基因并且有效地结合并感染相关的免疫细胞。