发明授权
US09127256B2 Method for production of reprogrammed cell using chromosomally unintegrated virus vector
有权
使用染色体非整合病毒载体生产重编程细胞的方法
- 专利标题: Method for production of reprogrammed cell using chromosomally unintegrated virus vector
- 专利标题(中): 使用染色体非整合病毒载体生产重编程细胞的方法
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申请号: US13054022申请日: 2009-07-16
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公开(公告)号: US09127256B2公开(公告)日: 2015-09-08
- 发明人: Noemi Fusaki , Hiroshi Ban , Mamoru Hasegawa , Yoshikazu Yonemitsu
- 申请人: Noemi Fusaki , Hiroshi Ban , Mamoru Hasegawa , Yoshikazu Yonemitsu
- 申请人地址: JP Ibaraki
- 专利权人: DNAVEC CORPORATION
- 当前专利权人: DNAVEC CORPORATION
- 当前专利权人地址: JP Ibaraki
- 代理机构: Clark & Elbing LLP
- 优先权: JP2008-185049 20080716; JP2008-258883 20081003; JP2009-126753 20090526
- 国际申请: PCT/JP2009/062911 WO 20090716
- 国际公布: WO2010/008054 WO 20100121
- 主分类号: C12N5/00
- IPC分类号: C12N5/00 ; C12N5/02 ; C12N5/074 ; C07K14/47
摘要:
An objective of the present invention is to provide vectors for conveniently and efficiently producing ES-like cells in which foreign genes are not integrated into the chromosome. The present inventors discovered methods for producing ES-like cells from somatic cells using chromosomally non-integrating viral vectors. Since no foreign gene is integrated into the chromosome of the produced ES-like cells, they are advantageous in tests and research, and immunological rejection and ethical problems can be avoided in disease treatments.
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