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1.发明申请METHOD FOR PRODUCTION OF REPROGRAMMED CELL USING CHROMOSOMALLY UNINTEGRATED VIRUS VECTOR 有权使用染色体非感染病毒载体生产复制细胞的方法公开(公告)号：US20110287538A1
公开(公告)日：2011-11-24
申请号：US13054022
申请日：2009-07-16
CPC分类号： C12N15/86 , C07K14/4702 , C12N5/0696 , C12N7/00 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2760/18622 , C12N2760/18643 , C12N2760/18645 , C12N2760/18662 , C12N2760/18822 , C12N2760/18843
摘要： An objective of the present invention is to provide vectors for conveniently and efficiently producing ES-like cells in which foreign genes are not integrated into the chromosome. The present inventors discovered methods for producing ES-like cells from somatic cells using chromosomally non-integrating viral vectors. Since no foreign gene is integrated into the chromosome of the produced ES-like cells, they are advantageous in tests and research, and immunological rejection and ethical problems can be avoided in disease treatments.
摘要翻译： 本发明的目的是提供用于方便和有效地产生外源基因未整合到染色体中的ES样细胞的载体。 本发明人发现使用染色体非整合型病毒载体从体细胞产生ES样细胞的方法。 由于没有外源基因整合到产生的ES样细胞的染色体中，因此在测试和研究中是有利的，并且在疾病治疗中可以避免免疫排斥和伦理问题。
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2.发明授权Method for production of reprogrammed cell using chromosomally unintegrated virus vector 有权使用染色体非整合病毒载体生产重编程细胞的方法公开(公告)号：US09127256B2
公开(公告)日：2015-09-08
申请号：US13054022
申请日：2009-07-16
CPC分类号： C12N15/86 , C07K14/4702 , C12N5/0696 , C12N7/00 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00 , C12N2760/18622 , C12N2760/18643 , C12N2760/18645 , C12N2760/18662 , C12N2760/18822 , C12N2760/18843
摘要： An objective of the present invention is to provide vectors for conveniently and efficiently producing ES-like cells in which foreign genes are not integrated into the chromosome. The present inventors discovered methods for producing ES-like cells from somatic cells using chromosomally non-integrating viral vectors. Since no foreign gene is integrated into the chromosome of the produced ES-like cells, they are advantageous in tests and research, and immunological rejection and ethical problems can be avoided in disease treatments.
摘要翻译： 本发明的目的是提供用于方便和有效地产生外源基因未整合到染色体中的ES样细胞的载体。 本发明人发现使用染色体非整合型病毒载体从体细胞产生ES样细胞的方法。 由于没有外源基因整合到产生的ES样细胞的染色体中，因此在测试和研究中是有利的，并且在疾病治疗中可以避免免疫排斥和伦理问题。
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公开(公告)号：US20130210150A1
公开(公告)日：2013-08-15
申请号：US13819235
申请日：2011-08-30
申请人： Hiroshi Ban , Yasuji Ueda , Noemi Fusaki , Koichi Saeki , Mamoru Hasegawa
发明人： Hiroshi Ban , Yasuji Ueda , Noemi Fusaki , Koichi Saeki , Mamoru Hasegawa
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N5/0696 , C12N15/63 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2506/13 , C12N2510/00 , C12N2760/18843
摘要： The present invention provides Sendai virus vectors in which genes that encode reprograming factors for inducing pluripotent stem cells are incorporated in a specific order, compositions comprising these vectors for gene delivery to be used in the induction of pluripotent stem cells, and uses thereof. Incorporation of the KLF gene, OCT gene, and SOX gene in a specific order into a single Sendai virus vector successfully and significantly increased the efficiency of pluripotent stem cell induction. Loading multiple reprogramming factors into a single vector can further increase the induction efficiency of pluripotent stem cells while reducing the number of necessary vectors.
摘要翻译： 本发明提供仙台病毒载体，其中编码用于诱导多能干细胞的重编程因子的基因以特定顺序并入，包含用于诱导多能干细胞的基因递送的载体的组合物及其用途。 将KLF基因，OCT基因和SOX基因以特定顺序并入单一仙台病毒载体中，并显着提高多能干细胞诱导的效率。 将多个重编程因子加载到单个载体中可以进一步增加多能干细胞的诱导效率，同时减少必需载体的数量。
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公开(公告)号：US09090909B2
公开(公告)日：2015-07-28
申请号：US13819235
申请日：2011-08-30
申请人： Hiroshi Ban , Yasuji Ueda , Noemi Fusaki , Koichi Saeki , Mamoru Hasegawa
发明人： Hiroshi Ban , Yasuji Ueda , Noemi Fusaki , Koichi Saeki , Mamoru Hasegawa
CPC分类号： C12N15/86 , C12N5/0696 , C12N15/63 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2506/13 , C12N2510/00 , C12N2760/18843
摘要： The present invention provides Sendai virus vectors in which genes that encode reprograming factors for inducing pluripotent stem cells are incorporated in a specific order, compositions comprising these vectors for gene delivery to be used in the induction of pluripotent stem cells, and uses thereof. Incorporation of the KLF gene, OCT gene, and SOX gene in a specific order into a single Sendai virus vector successfully and significantly increased the efficiency of pluripotent stem cell induction. Loading multiple reprogramming factors into a single vector can further increase the induction efficiency of pluripotent stem cells while reducing the number of necessary vectors.
摘要翻译： 本发明提供仙台病毒载体，其中编码用于诱导多能干细胞的重编程因子的基因以特定顺序并入，包含用于诱导多能干细胞的基因递送的载体的组合物及其用途。 将KLF基因，OCT基因和SOX基因以特定顺序并入单一仙台病毒载体中，并显着提高多能干细胞诱导的效率。 将多个重编程因子加载到单个载体中可以进一步增加多能干细胞的诱导效率，同时减少必需载体的数量。
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