Invention Grant
US09133487B2 Microorganisms for producing methacrylic acid and methacrylate esters and methods related thereto
有权
用于生产甲基丙烯酸和甲基丙烯酸酯的微生物及其相关方法
- Patent Title: Microorganisms for producing methacrylic acid and methacrylate esters and methods related thereto
- Patent Title (中): 用于生产甲基丙烯酸和甲基丙烯酸酯的微生物及其相关方法
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Application No.: US13436811Application Date: 2012-03-30
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Publication No.: US09133487B2Publication Date: 2015-09-15
- Inventor: Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
- Applicant: Mark J. Burk , Anthony P. Burgard , Robin E. Osterhout , Jun Sun , Priti Pharkya
- Applicant Address: US CA San Diego
- Assignee: GENOMATICA, INC.
- Current Assignee: GENOMATICA, INC.
- Current Assignee Address: US CA San Diego
- Agency: Kagan Binder, PLLC
- Main IPC: C12N1/12
- IPC: C12N1/12 ; C12N1/20 ; C12P7/40 ; C12P19/32 ; C12P7/42 ; C12P7/62

Abstract:
The invention provides a non-naturally occurring microbial organism having a methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a methacrylic acid pathway. The invention additionally provides a method for producing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate. The method can include culturing methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate producing microbial organism, where the microbial organism expresses at least one exogenous nucleic acid encoding a methacrylic acid pathway enzyme in a sufficient amount to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate, under conditions and for a sufficient period of time to produce methacrylic acid, methacrylate ester, 3-hydroxyisobutyrate and/or 2-hydroxyisobutyrate.
Public/Granted literature
- US20130065279A1 MICROORGANISMS FOR PRODUCING METHACRYLIC ACID AND METHACRYLATE ESTERS AND METHODS RELATED THERETO Public/Granted day:2013-03-14
Information query
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