发明授权
US09133496B2 Material for screening for compound acting on ion channel and use thereof
有权
用于筛选作用于离子通道的化合物的材料及其用途
- 专利标题： Material for screening for compound acting on ion channel and use thereof
- 专利标题（中）： 用于筛选作用于离子通道的化合物的材料及其用途
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申请号： US13807464申请日： 2011-06-29
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公开(公告)号： US09133496B2公开(公告)日： 2015-09-15
- 发明人: Yuji Imaizumi , Masato Fujii , Susumu Ohya , Hisao Yamamura
- 申请人： Yuji Imaizumi , Masato Fujii , Susumu Ohya , Hisao Yamamura
- 申请人地址： JP Aichi JP Aichi
- 专利权人： PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY,CHANNELOSEARCH TECHNOLOGY
- 当前专利权人： PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY,CHANNELOSEARCH TECHNOLOGY
- 当前专利权人地址： JP Aichi JP Aichi
- 代理机构： Oliff PLC
- 优先权： JP2010-147255 20100629
- 国际申请： PCT/JP2011/064967 WO 20110629
- 国际公布： WO2012/002460 WO 20120105
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12Q1/02 ; C07K14/705 ; G01N33/68 ; C12N5/00 ; C12N5/02 ; C12N5/071 ; C12N5/10 ; C12N5/16 ; G01N33/48
摘要：
An object of the present invention is to provide a screening system that targets ion channels and has superior efficiency. The present invention provides a material for screening for compounds that act on a target ion channel, comprising cells which retain at least one first DNA encoding a voltage-dependent Na ion channel that has been inhibited from being inactivated, and in which a K ion channel has been activated so that a resting membrane potential becomes deeper in a negative direction.
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