发明授权
US09150605B2 Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
有权
包含交替的2'-修饰核苷的组合物用于基因调控
- 专利标题： Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
- 专利标题（中）： 包含交替的2'-修饰核苷的组合物用于基因调控
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申请号： US10860265申请日： 2004-06-03
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公开(公告)号： US09150605B2公开(公告)日： 2015-10-06
- 发明人: Charles Allerson , Balkrishen Bhat , Anne B. Eldrup , Muthiah Manoharan , Richard H. Griffey , Brenda F. Baker , Eric E. Swayze
- 申请人： Charles Allerson , Balkrishen Bhat , Anne B. Eldrup , Muthiah Manoharan , Richard H. Griffey , Brenda F. Baker , Eric E. Swayze
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 代理机构： Baker Hofstetler
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/00 ; C07H21/04 ; C12N15/11 ; C12N15/113
摘要：
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
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