Invention Grant
- Patent Title: 4-piperidinyl compounds for use as tankyrase inhibitors
- Patent Title (中): 用作阻聚酶抑制剂的4-哌啶基化合物
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Application No.: US14154173Application Date: 2012-07-13
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Publication No.: US09163003B2Publication Date: 2015-10-20
- Inventor: Christine Hiu-Tung Chen , Donovan Noel Chin , Lucien V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
- Applicant: Christine Hiu-Tung Chen , Donovan Noel Chin , Lucien V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
- Applicant Address: CH Basel
- Assignee: NOVARTIS AG
- Current Assignee: NOVARTIS AG
- Current Assignee Address: CH Basel
- Agent Qian Zhang
- International Application: PCT/IB2012/053613 WO 20120713
- International Announcement: WO2013/008217 WO 20130117
- Main IPC: C07D491/052
- IPC: C07D491/052 ; C07D493/04 ; C07D401/12 ; C07D401/04 ; C07D401/14 ; C07D471/04 ; C07D487/04 ; C07D491/04 ; C07D495/04 ; C07D498/04 ; C07D513/04
Abstract:
The present invention provides for compounds of formula (I): wherein R1-R4 and n are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
Public/Granted literature
- US20150126513A1 4-PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS Public/Granted day:2015-05-07
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