-
公开(公告)号：US09163003B2
公开(公告)日：2015-10-20
申请号：US14154173
申请日：2012-07-13
申请人： Christine Hiu-Tung Chen , Donovan Noel Chin , Lucien V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
发明人： Christine Hiu-Tung Chen , Donovan Noel Chin , Lucien V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
IPC分类号： C07D491/052 , C07D493/04 , C07D401/12 , C07D401/04 , C07D401/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/052 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention provides for compounds of formula (I): wherein R1-R4 and n are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物：其中R 1 -R 4和n如本文所定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
-
公开(公告)号：US20150126513A1
公开(公告)日：2015-05-07
申请号：US14154173
申请日：2012-07-13
申请人： Christine Hiu-Tung Chen , Donovan Noel Chin , Lucian V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
发明人： Christine Hiu-Tung Chen , Donovan Noel Chin , Lucian V. DiPietro , Jianmei Fan , Mark G. Palermo , Michael David Shultz , Bakary-Barry Toure
IPC分类号： C07D401/04 , C07D487/04 , C07D498/04 , C07D401/14 , C07D513/04 , C07D471/04 , C07D491/052 , C07D495/04
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/052 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention provides for compounds of formula (I): wherein R1-R4 and n are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物：其中R 1 -R 4和n如本文所定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
-
3.发明授权公开(公告)号：US09181266B2
公开(公告)日：2015-11-10
申请号：US14154161
申请日：2012-07-13
申请人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Karen Marie Miller-Moslin , Michael David Shultz , Troy D Smith , Ronald Charles Tomlinson , Bakary-Barry Toure , Michael Scott Visser , Zhuoliang Chen
发明人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Karen Marie Miller-Moslin , Michael David Shultz , Troy D Smith , Ronald Charles Tomlinson , Bakary-Barry Toure , Michael Scott Visser , Zhuoliang Chen
IPC分类号： C07D401/12 , C07D409/14 , A61K31/453 , A61K31/4545 , C07D491/052 , C07D493/04
CPC分类号： C07D491/052 , A61K31/453 , A61K31/4545 , C07D401/12 , C07D409/14 , C07D493/04
摘要： The present invention provides for compounds of formula (I): wherein R1-R5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物：其中R1-R5和L在本文中定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
-
4.发明申请NOVEL 2-PIPERIDIN-1-YL-ACETAMIDE COMPOUNDS FOR USE AS TANKYRASE INHIBITORS 有权新型2-哌啶-1-基乙酰胺化合物用作丹麦酯抑制剂公开(公告)号：US20150025070A1
公开(公告)日：2015-01-22
申请号：US14154161
申请日：2012-07-13
申请人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Karen Marie Miller-Moslin , Michael David Shultz , Troy D. Smith , Ronald Charles Tomlinson , Bakary-Barry Toure , Michael Scott Visser
发明人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Karen Marie Miller-Moslin , Michael David Shultz , Troy D. Smith , Ronald Charles Tomlinson , Bakary-Barry Toure , Michael Scott Visser
IPC分类号： C07D491/052 , C07D493/04 , C07D401/12
CPC分类号： C07D491/052 , A61K31/453 , A61K31/4545 , C07D401/12 , C07D409/14 , C07D493/04
摘要： The present invention provides for compounds of formula (I): wherein R1-R5 and L are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物：其中R1-R5和L在本文中定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
-
![4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors](/abs-image/US/2016/01/05/US09227982B2/abs.jpg.150x150.jpg)
5.发明授权4-oxo-3,5,7,8-tetrahydro-4H-pyrano[4,3-d]pyrminidinyl compounds for use as tankyrase inhibitors 有权用作阻聚酶抑制剂的4-氧代-3,5,7,8-四氢-4H-吡喃并[4,3-d]嘧啶基化合物公开(公告)号：US09227982B2
公开(公告)日：2016-01-05
申请号：US14154170
申请日：2012-07-13
申请人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Michael David Shultz , Ronald Charles Tomlinson
发明人： Atwood Kim Cheung , Donovan Noel Chin , Jianmei Fan , Michael David Shultz , Ronald Charles Tomlinson
IPC分类号： A01N43/90 , A61K31/519 , C07D491/00 , C07D495/00 , C07D491/052
CPC分类号： C07D491/052 , A61K31/519
摘要： The present invention provides for compounds of formula (I) wherein R1 and R2 are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.
摘要翻译： 本发明提供式（I）化合物，其中R 1和R 2在本文中定义。 本发明还提供药物组合物和组合物，其包含式（I）化合物以及使用这些化合物作为阻断酶抑制剂和用于治疗Wnt信号传导和阻断酶1和2信号传导相关疾病，其包括但是是 不限于癌症。
-
公开(公告)号：US08349883B2
公开(公告)日：2013-01-08
申请号：US13082956
申请日：2011-04-08
申请人： Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
发明人： Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
IPC分类号： A61K31/4162 , A61K31/4155
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，Y，Z如本文所定义。 本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。
-
公开(公告)号：US20090247547A1
公开(公告)日：2009-10-01
申请号：US12411715
申请日：2009-03-26
申请人： Michael SHULTZ , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar
发明人： Michael SHULTZ , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar
IPC分类号： A61K31/496 , C07D209/04 , A61K31/404 , C12N5/00 , C07D261/06 , A61K31/42 , C07D231/10 , A61K31/415 , C07D471/02 , A61K31/437 , C07D207/00 , A61K31/40 , C07D401/02 , A61K31/4439 , C07D403/14 , A61K31/497 , A61P35/00 , A61P25/00 , A61P37/06 , A61P29/00 , A61P31/10
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R1，R2，R3，Y，Z和
如本文所定义。 本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。
-
公开(公告)号：US07943652B2
公开(公告)日：2011-05-17
申请号：US12411715
申请日：2009-03-26
申请人： Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
发明人： Michael D. Shultz , Christine Hiu-Tung Chen , Young Shin Cho , Lei Jiang , Jianmei Fan , Gang Liu , Dyuti Majumdar , Jianke Li
IPC分类号： A61K31/4162 , A61K31/4155 , C07D487/04 , C07D231/10
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein. The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，Y，Z如本文所定义。 本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。
-
9.发明申请PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权用于治疗与促血细胞生成相关的高血压疾病和疾病的吡咯烷酮衍生物公开(公告)号：US20100075958A1
公开(公告)日：2010-03-25
申请号：US12506033
申请日：2009-07-20
申请人： Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C.E. Kluender
发明人： Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C.E. Kluender
IPC分类号： A61K31/53 , C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号： C07D491/113 , C07D487/04
摘要： This invention relates to pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译： 本发明涉及吡咯并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性病症和疾病的用途。
-
10.发明申请Benzofuran and benzothiophene derivatives useful in the treatmint of hyper-proliferative disorders 失效苯并呋喃和苯并噻吩衍生物可用于高增殖性疾病的治疗公开(公告)号：US20050139814A1
公开(公告)日：2005-06-30
申请号：US10501689
申请日：2003-02-21
申请人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
发明人： Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
IPC分类号： A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/422 , A61K31/427 , A61K31/4355 , A61K31/443 , A61K31/4436 , A61K31/455 , A61K31/497 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P35/04 , B66F3/36 , C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D491/048 , C07D493/04
CPC分类号： C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要： This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译： 本发明涉及通用表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
-
-
-
-
-
-
-
-
-
搜索结果
25 条记录 (耗时 0.043 秒)
