发明授权
- 专利标题： Engineering individually addressable cellular spheroids using aqueous two-phase systems
- 专利标题（中）： 使用水相两相系统工程化单独寻址细胞球体
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申请号： US14064886申请日： 2013-10-28
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公开(公告)号： US09176115B2公开(公告)日： 2015-11-03
- 发明人: Hossein Tavana , Ehsan Atefi , Stephanie Lemmo Ham
- 申请人： Hossein Tavana , Ehsan Atefi , Stephanie Lemmo Ham
- 申请人地址： US OH Akron
- 专利权人： The University of Akron
- 当前专利权人： The University of Akron
- 当前专利权人地址： US OH Akron
- 代理机构： Renner Kenner Greive Bobak Taylor & Weber
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; C12N5/00
摘要：
Provided is multi-phase systems that may be used to prepare a three-dimension aggregate of cells referred to as a cellular spheroid. The multi-phase system includes a droplet of an aqueous polymer phase within an immersion aqueous polymer phase. The droplet of the droplet aqueous polymer phase contains a three-dimensional aggregate of cells (cellular spheroid). Types of cells that may be used in the multi-phases system include stem cells and cancer cells. The cellular spheroids with the multi-phase system may be used to monitor cell growth in three-dimensional systems, or screen drugs in a three-dimension aggregate of cells.