公开(公告)号：US20160091487A1

公开(公告)日：2016-03-31

申请号：US14870910

申请日：2015-09-30

申请人： Hossein Tavana ,  Ehsan Atefi ,  Stephanie Lemmo Ham

发明人： Hossein Tavana ,  Ehsan Atefi ,  Stephanie Lemmo Ham

IPC分类号： G01N33/50 ,  C12N11/10

CPC分类号： G01N33/5011 ,  C12N5/0062 ,  C12N11/10 ,  C12N2500/50 ,  G01N33/5008 ,  G01N33/5073 ,  G01N2500/10

摘要： Provided are multi-phase systems that may be used to prepare a three-dimension aggregate of cells referred to as a cellular spheroid. The multi-phase system includes a droplet of an aqueous polymer phase within an immersion aqueous polymer phase. The droplet of the droplet aqueous polymer phase contains a three-dimensional aggregate of cells (cellular spheroid). Types of cells that may be used in the multi-phases system include stem cells and cancer cells. The cellular spheroids with the multi-phase system may be used to monitor cell growth in three-dimensional systems, or screen drugs in a three-dimension aggregate of cells.

摘要翻译： 提供了可用于制备称为细胞球体的细胞的三维聚集体的多相系统。 多相系统包括浸渍含水聚合物相内的聚合物水相的液滴。 液滴聚合物液滴的液滴含有细胞的三维聚集体（细胞球状体）。 可用于多相系统的细胞的类型包括干细胞和癌细胞。 具有多相系统的细胞球体可用于监测三维体系中的细胞生长或三维细胞聚集体中的筛选药物。

公开(公告)号：US09176115B2

公开(公告)日：2015-11-03

申请号：US14064886

申请日：2013-10-28

申请人： Hossein Tavana ,  Ehsan Atefi ,  Stephanie Lemmo Ham

发明人： Hossein Tavana ,  Ehsan Atefi ,  Stephanie Lemmo Ham

IPC分类号： G01N33/50 ,  C12N5/00

CPC分类号： G01N33/5011 ,  C12N5/0062 ,  C12N11/10 ,  C12N2500/50 ,  G01N33/5008 ,  G01N33/5073 ,  G01N2500/10

摘要： Provided is multi-phase systems that may be used to prepare a three-dimension aggregate of cells referred to as a cellular spheroid. The multi-phase system includes a droplet of an aqueous polymer phase within an immersion aqueous polymer phase. The droplet of the droplet aqueous polymer phase contains a three-dimensional aggregate of cells (cellular spheroid). Types of cells that may be used in the multi-phases system include stem cells and cancer cells. The cellular spheroids with the multi-phase system may be used to monitor cell growth in three-dimensional systems, or screen drugs in a three-dimension aggregate of cells.

摘要翻译： 提供了可用于制备被称为细胞球体的细胞的三维聚集体的多相系统。 多相系统包括浸渍含水聚合物相内的聚合物水相的液滴。 液滴聚合物液滴的液滴含有细胞的三维聚集体（细胞球状体）。 可用于多相系统的细胞的类型包括干细胞和癌细胞。 具有多相系统的细胞球体可用于监测三维体系中的细胞生长或三维细胞聚集体中的筛选药物。

公开(公告)号：US09874552B2

公开(公告)日：2018-01-23

申请号：US14870910

申请日：2015-09-30

申请人： Hossein Tavana ,  Ehsan Atefi ,  Stephanie Lemmo Ham

发明人： Hossein Tavana ,  Ehsan Atefi ,  Stephanie Lemmo Ham

IPC分类号： G01N33/50 ,  C12N5/00 ,  C12N11/10

CPC分类号： G01N33/5011 ,  C12N5/0062 ,  C12N11/10 ,  C12N2500/50 ,  G01N33/5008 ,  G01N33/5073 ,  G01N2500/10

摘要： Provided are multi-phase systems that may be used to prepare a three-dimension aggregate of cells referred to as a cellular spheroid. The multi-phase system includes a droplet of an aqueous polymer phase within an immersion aqueous polymer phase. The droplet of the droplet aqueous polymer phase contains a three-dimensional aggregate of cells (cellular spheroid). Types of cells that may be used in the multi-phases system include stem cells and cancer cells. The cellular spheroids with the multi-phase system may be used to monitor cell growth in three-dimensional systems, or screen drugs in a three-dimension aggregate of cells.