发明授权
US09176151B2 Antibodies, kit and method for detecting amyloid beta oligomers
有权
用于检测淀粉样β寡聚体的抗体，试剂盒和方法
- 专利标题： Antibodies, kit and method for detecting amyloid beta oligomers
- 专利标题（中）： 用于检测淀粉样β寡聚体的抗体，试剂盒和方法
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申请号： US13544600申请日： 2012-07-09
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公开(公告)号： US09176151B2公开(公告)日： 2015-11-03
- 发明人: William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
- 申请人： William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
- 申请人地址： US CA Livermore
- 专利权人： Acumen Pharmaceuticals, Inc.
- 当前专利权人： Acumen Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Livermore
- 代理机构： Licata & Tyrrell P.C.
- 主分类号： C07K16/18
- IPC分类号： C07K16/18 ; G01N33/532 ; G01N33/68
摘要：
This invention is a selective Aβ oligomer kit and immunoassay method capable of reliably and sensitively detecting Aβ oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-Aβ oligomer antibodies, as capture and detection antibodies, to detect and quantify Aβ oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease.