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1.
公开(公告)号:US09176151B2
公开(公告)日:2015-11-03
申请号:US13544600
申请日:2012-07-09
申请人: William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
发明人: William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
IPC分类号: C07K16/18 , G01N33/532 , G01N33/68
CPC分类号: G01N33/6896 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/4709 , G01N2800/2821
摘要: This invention is a selective Aβ oligomer kit and immunoassay method capable of reliably and sensitively detecting Aβ oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-Aβ oligomer antibodies, as capture and detection antibodies, to detect and quantify Aβ oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease.
摘要翻译: 本发明是一种选择性的 低聚物试剂盒和免疫测定法,能够可靠而灵敏地检测A&bgr; 患者生物样品中的低聚物。 在一个实施方案中,本发明的测定使用一对抗A&bgr; 低聚物抗体作为捕获和检测抗体,用于检测和定量A&bgr; 低聚物。 该方法可用于区分阿尔茨海默病(AD)患者和非AD患者和/或根据其疾病的严重程度分层AD患者。
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公开(公告)号:US20130115227A1
公开(公告)日:2013-05-09
申请号:US13809475
申请日:2011-07-13
申请人: Renee C. Gaspar , Paul J. Shughrue , Fubao Wang , Weirong Wang , Ningyan Zhang , Wei-Qin Zhao , Min Xu , Alexander McCampbell
发明人: Renee C. Gaspar , Paul J. Shughrue , Fubao Wang , Weirong Wang , Ningyan Zhang , Wei-Qin Zhao , Min Xu , Alexander McCampbell
IPC分类号: C07K16/18
CPC分类号: C07K16/18 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要: Disclosed are antibodies that bind amyloid beta-derived diffusible ligands, also known as ADDLs. The antibodies are selective for ADDLs, can penetrate the brain, and are useful in methods of detecting ADDLs and diagnosing Alzheimer's disease. The antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with ADDLs.
摘要翻译: 公开了结合淀粉样蛋白β-衍生的扩散配体(也称为ADDL)的抗体。 抗体对ADDL是有选择性的,可以渗透大脑,并且可用于检测ADDLs和诊断阿尔茨海默氏病的方法。 抗体还阻断ADDL与神经元的结合,ADDLS的组装和tau磷酸化,并且在用于预防和治疗与ADDL相关的疾病的方法中是有用的。
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3.
公开(公告)号:US20130130288A1
公开(公告)日:2013-05-23
申请号:US13544600
申请日:2012-07-09
申请人: William F. Goure
发明人: William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
IPC分类号: G01N33/68
CPC分类号: G01N33/6896 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/4709 , G01N2800/2821
摘要: This invention is a selective Aβ oligomer kit and immunoassay method capable of reliably and sensitively detecting Aβ oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-Aβ oligomer antibodies, as capture and detection antibodies, to detect and quantify Aβ oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease.
摘要翻译: 本发明是一种能够可靠和敏感地检测患者生物样品中的Aβ寡聚体的选择性Abeta寡聚体试剂盒和免疫测定方法。 在一个实施方案中,本发明的测定使用一对抗Abeta寡聚体抗体作为捕获和检测抗体来检测和定量Aβ寡聚体。 该方法可用于区分阿尔茨海默病(AD)患者和非AD患者和/或根据其疾病的严重程度分层AD患者。
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