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1.
公开(公告)号:US09176151B2
公开(公告)日:2015-11-03
申请号:US13544600
申请日:2012-07-09
申请人: William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
发明人: William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
IPC分类号: C07K16/18 , G01N33/532 , G01N33/68
CPC分类号: G01N33/6896 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/4709 , G01N2800/2821
摘要: This invention is a selective Aβ oligomer kit and immunoassay method capable of reliably and sensitively detecting Aβ oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-Aβ oligomer antibodies, as capture and detection antibodies, to detect and quantify Aβ oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease.
摘要翻译: 本发明是一种选择性的 低聚物试剂盒和免疫测定法,能够可靠而灵敏地检测A&bgr; 患者生物样品中的低聚物。 在一个实施方案中,本发明的测定使用一对抗A&bgr; 低聚物抗体作为捕获和检测抗体,用于检测和定量A&bgr; 低聚物。 该方法可用于区分阿尔茨海默病(AD)患者和非AD患者和/或根据其疾病的严重程度分层AD患者。
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2.
公开(公告)号:US20130130288A1
公开(公告)日:2013-05-23
申请号:US13544600
申请日:2012-07-09
申请人: William F. Goure
发明人: William F. Goure , Renee C. Gaspar , Alexander McCampbell , Mary J. Savage , Paul J. Shughrue , Fubao Wang , Weirong Wang , Abigail L. Wolfe , Nigyan Zhang , Wei-Qin Zhao
IPC分类号: G01N33/68
CPC分类号: G01N33/6896 , C07K16/18 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/4709 , G01N2800/2821
摘要: This invention is a selective Aβ oligomer kit and immunoassay method capable of reliably and sensitively detecting Aβ oligomers in a biological sample of a patient. In one embodiment the inventive assay uses a pair of anti-Aβ oligomer antibodies, as capture and detection antibodies, to detect and quantify Aβ oligomers. The method can be used to differentiate Alzheimer's disease (AD) patients from non-AD patients and/or to stratify AD patients according to the severity of their disease.
摘要翻译: 本发明是一种能够可靠和敏感地检测患者生物样品中的Aβ寡聚体的选择性Abeta寡聚体试剂盒和免疫测定方法。 在一个实施方案中,本发明的测定使用一对抗Abeta寡聚体抗体作为捕获和检测抗体来检测和定量Aβ寡聚体。 该方法可用于区分阿尔茨海默病(AD)患者和非AD患者和/或根据其疾病的严重程度分层AD患者。
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